To evaluate the use of the CAMbridge PROstate Biopsy devicE (CAMPROBE) as a method of undertaking prostate biopsy as part of their clinical management.

To assess patient's experience and complications of the CAMPROBE and compare the results with known published outcomes from standard transrectal biopsies .

To use data from the pilot study to determine the feasibility of a randomised trial comparing CAMPROBE with the current standard method of prostate biopsies.

Inclusion Criteria:

• Fit and well enough to undergo a repeat prostate biopsy
• Men who have previously had a transrectal ultrasound biopsy of the prostate and due to have a repeat biopsy as part of normal care
• Men on active surveillance
• Men on PSA monitoring

Exclusion Criteria:

• Contraindication for a repeat prostate biopsy
• Contraindication for a transperineal prostate biopsies
• Previous perineal or anal surgery
• MRI suggesting anterior lesion or extra capsular disease
• MRI suggesting lesion that needs fusion image targeting
• Unable to lie down and with legs in a stirrup for at least 45 minutes

Subjects who have had a standard biopsy and now require a transrectal biopsy as part of their management