Salpingectomy at Cesarean Delivery for Ovarian Cancer Reduction (SCORE)

Complete Salpingectomy Versus Standard Postpartum Tubal Ligation at the Time of Cesarean Delivery- a Randomized Controlled Study

To compare the feasibility and surgical outcomes between complete salpingectomy and standard postpartum tubal ligation (partial salpingectomy) at the time of cesarean delivery in women with undesired future fertility. as a possible ovarian cancer risk-reducing procedure.

All pregnant women receiving prenatal care within the UAB Health System, and planning to undergo tubal ligation at the time of their scheduled cesarean delivery (primary or repeat) will be approached about the study. Patients will be randomized to receive either the standard tubal ligation practice at our institution (modified Pomeroy procedure or Parkland) or a complete salpingectomy. The objective of this trial is to evaluate if a complete salpingectomy can be performed safely and comparable to a standard postpartum tubal ligation.

Inclusion Criteria:

• All pregnant women > 25 years receiving prenatal care within the UAB Health System, and planning to undergo tubal ligation at the time of their scheduled cesarean delivery (primary or repeat)
• Informed consent obtained

Exclusion Criteria:

• Inability to obtain informed consent
• Fetal death or anomalies
• Preterm delivery < 36 weeks gestation
• Immune-compromising disease
• Chronic steroid use
• Chronic prophylactic or therapeutic anti-coagulation
• Patients no followed in our regional health system
• Known BRCA mutation carrier status
• Age < 25 years