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Asthma in the elderly is poorly understood, as most studies have not included this patient group. In a previous study of adults with asthma, choline supplementation had a positive effect on asthma symptoms and allowed to decrease asthma pharmacologic treatment. The present study is a randomized, double-blind, placebo-controlled, cross-over study of choline supplementation. The investigators will study the effect of choline 650 mg taken orally twice daily x 6 weeks versus placebo on asthma symptom scores (Asthma Control Test) and spirometric values (FEV1, FEV1/FVC, FEF25-75%). The investigators will also look at the effect of choline supplementation on peripheral blood eosinophils, serum immunoglobulin E (IgE) and homocysteine levels.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Choline 650 mg twice daily | Experimental | See above |
|
| Placebo | Placebo Comparator | See above |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Choline | Dietary Supplement |
| ||
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of choline supplementation on asthma symptoms measured by the Asthma Control Test | six weeks | |
| Effect of choline supplementation on spirometric values (FEV1, FEV1/FVC, FEF25-75%) | six weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of choline supplementation on peripheral blood eosinophils | six weeks | |
| Effect of choline supplementation on serum IgE | six weeks | |
| Effect of choline supplementation on serum homocysteine levels |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michele Columbo, M.D. | Rohr and Columbo Asthma, Allergy and Immunology Specialists | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rohr and Columbo Asthma, Allergy and Immunology Specialists, P.C. | Bryn Mawr | Pennsylvania | 19010 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26973701 | Derived | Columbo M, Rohr AS. Asthma in the elderly: the effect of choline supplementation. Allergy Asthma Clin Immunol. 2016 Mar 11;12:15. doi: 10.1186/s13223-016-0121-5. eCollection 2016. |
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| ID | Term |
|---|---|
| D002794 | Choline |
| ID | Term |
|---|---|
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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| Other |
|
| six weeks |
| D000588 |
| Amines |
| D050337 | Trimethyl Ammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D009861 | Onium Compounds |