Multimodal Pain Management Following Primary TKA

Periarticular Infusion With Liposomal Bupivacaine or a Ropivacaine Cocktail Versus Continuous Femoral Nerve Catheters for Multimodal Pain Management Following Primary TKA: A Randomized Controlled Trial

The investigators plan to evaluate the length of time to discharge readiness between the groups (continuous femoral nerve blocks (cFNB) vs. liposomal bupivacaine (LB) vs. periarticular infusion cocktails (PIC) following primary total knee arthroplasty (TKA). In addition, the investigators will compare quadriceps strength recovery over time and exploratory variables between the groups.

Inclusion Criteria:

• ≥ 40 Years Old
• Scheduled for Primary Total Knee Arthroplasty

Exclusion Criteria:

• Opiate Tolerant (≥60mg/day oral morphine/equivalent for ≥1 week)

• Neuromuscular deficit affecting the lower limbs

  • Peripheral neuropathy
  • Radiculopathy/Sciatica

• Known allergy or intolerance to Bupivacaine or Ropivacaine

• Hepatic Disease

• Renal Disease/Patients needing Dialysis

• Planned unicompartmental knee replacement

• Less than 90 degree of knee flexion preoperatively.

• Patients who lack the capacity to consent or are unwilling to do so

• At the discretion of the PI, patients who may have difficulty complying with standard of care (SOC) followup may also be excluded