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| Name | Class |
|---|---|
| University Hospital, Lille | OTHER |
| University Hospital, Rouen | OTHER |
| University Hospital, Caen | OTHER |
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Background: The cardiac resynchronization therapy (CRT) has been shown to improve symptoms and outcome of patients with congestive heart failure (HF), and depressed left ventricular ejection fraction (LVEF < 35 %). The rate of non-responders to CRT is estimated at 30 %. Yet, the impact of frailty on the response to CRT has not been studied, until now.
Purpose : To assess the impact of frailty in the elderly, on the response to CRT.
Methods : Frailty is evaluated before implant ,and defined as <14/17 points using the ONCODAGE score, in 150 patients of > 70 years age, selected for CRT according to the ESC 2013 guidelines. The response to CRT, estimated at 9 months, is defined as an improvement of at least 5 % of the LVEF and the absence of HF hospitalization or cardiovascular death.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CRT | Patients over 70 years age, selected for CRT according to the ESC 2013 guidelines. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Frailty | Other | CRT device is implanted in all patients selected for the study. Frailty is evaluated before implant and defined as <14/17 points using the ONCODAGE score |
|
| Measure | Description | Time Frame |
|---|---|---|
| non response on CRT | 9 months |
| Measure | Description | Time Frame |
|---|---|---|
| seric albumin | To assess the impact of seric albumin on the response to CRT | 9 months |
| seric gammaglutamyltranferase | To assess the impact of seric gammaglutamyltranferase on the response to CRT |
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Inclusion Criteria:
Exclusion Criteria:
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Patients of > 70 years age, selected for CRT according to the ESC 2013 guidelines
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| Name | Affiliation | Role |
|---|---|---|
| Maciej KUBALA | CHU Amiens | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU; Service de Cardiologie, Rythmologie et Stimulation cardiaque | Amiens | 80000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29759834 | Derived | Kubala M, Guedon-Moreau L, Anselme F, Klug D, Bertaina G, Traulle S, Buiciuc O, Savoure A, Diouf M, Hermida JS. Utility of Frailty Assessment for Elderly Patients Undergoing Cardiac Resynchronization Therapy. JACC Clin Electrophysiol. 2017 Dec 26;3(13):1523-1533. doi: 10.1016/j.jacep.2017.06.012. Epub 2017 Sep 13. |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D000073496 | Frailty |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| 9 months |
| mortality | 9 months |