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The current study examines the effect of phototherapy equipped with Narrow Band UVB lamps on vitamin D production in persons with MS.
Participants will be exposed to phototherapy according to the 2014 Guidelines issued by the American Academy of Dermatology 3 days per week over an 8-week period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Phototherapy | Experimental | This arm involves exposure to a UVB phototherapy device 3 times per week over 8 weeks. |
|
| Shame phototherapy | Placebo Comparator | This arm is identical with experimental arm, except that participants will be exposed to non-UVB florescent light. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Phototherapy | Device | Participants will be exposed to phototherapy according to the 2014 Guidelines issued by the American Academy of Dermatology 3 days per week over an 8-week period. |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline in Serum Vitamin D at 4 and 8 weeks | Venous blood will be collected to quantify levels of circulating Vitamin D. | 0, 4, and 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline in Walking Speed at 4 and 8 weeks | Participants will walking for 25-feet as fast, but safely, as possible on an instrumented gait mat for measuring gait speed. | 0, 4, and 8 weeks |
| Change from Baseline in Cognitive Function at 4 and 8 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Robert W Motl, PhD | University of Illinois at Urbana-Champaign | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Exercise Neuroscience Research Laboratory | Urbana | Illinois | 61801 | United States |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| ID | Term |
|---|---|
| D010789 | Phototherapy |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
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Participants will complete neuropsychological assessments of processing speed and learning and memory. |
| 0, 4, and 8 weeks |
| Change from Baseline in Mood State at 4 and 8 weeks | Participants will complete a 30-item self-report measure of overall mood. | 0, 4, and 8 weeks |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |