Mitochondrial Oxidative Stress and Vascular Health in Chronic Kidney Disease

Mitochondrial Oxidative Stress and Vascular Health in Chronic Kidney Disease

The purpose of this study is to examine the effect of mitochondria derived oxidative stress on vascular function in patients with moderate to severe Chronic Kidney Disease.

Chronic Kidney Disease (CKD) patients are at increased risk of cardiovascular disease. Endothelial dysfunction, characterized by a reduced bioavailability in nitric oxide, is an independent predictor of cardiovascular disease in CKD. Increased oxidative stress is a potential cause of endothelial dysfunction in this patient cohort. This study investigates the role that mitochondrial derived oxidative stress plays in CKD related vascular dysfunction. In a controlled, double blinded trial, Stage 3-5 CKD patients will be randomly assigned to receive a 4 week daily dose of a mitochondria targeted antioxidant (MitoQ) or a placebo.

Inclusion Criteria:

• Stage 3 - 5 Chronic Kidney Disease

Exclusion Criteria:

• History of cardiovascular disease;
• Current pregnancy;
• Uncontrolled hypertension;
• Uncontrolled hyperlipidemia;
• Current hormone replacement therapy;
• Current use of tobacco products;
• Elevated liver enzymes;
• Current autoimmune disease;
• Daily use of of antioxidants >300mg