A Comparative Study on Local Allergic Responses of Bee Venom and Essential Bee Venom Pharmacopuncture

A Comparative Study on Local Allergic Responses of Bee Venom and Essential Bee Venom Pharmacopuncture

This double-blinded randomized clinical trial investigates any differences in allergic responses elicited by Bee Venom (BV) and Essential Bee Venom (eBV).

This double-blinded randomized clinical trial investigates difference in allergic responses elicited by Bee Venom (BV) and Essential Bee Venom (eBV). Twenty healthy volunteers aged 20-40 years were randomly allocated to the 2 groups and administered eBV and BV on left and right forearm, respectively, in accordance with group allocation. Physician, participant, and outcome assessor were blinded to group allocation. Local pain, swelling, itching, redness, wheals and adverse reactions were recorded by timepoint before and after treatment.

Inclusion Criteria:

• Individuals with no prior exposure to bee venom treatment
• Healthy individuals of both genders, 20 to 39 years old
• Individuals able to communicate their thoughts
• Voluntary participants who have provided written consent

Exclusion Criteria:

• Individuals on medications for chronic diseases (i.e. hypertension, hyperlipidemia)
• Individuals with past history of allergic dermatitis
• Individuals with past history of adverse events following bee stings
• Individuals with symptoms of common cold
• Individuals with fear of bee venom intervention or those who refuse to participate