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| Name | Class |
|---|---|
| Dr. Michael Boschmann, Experimental & Clinical Research Center(ECRC), Charité Berlin-Buch | UNKNOWN |
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The primary purpose of this study is to determine whether a prewarming period of at least 30 minutes during induction of general and combined epidural anesthesia reduces the core temperature drop normally occuring in patients undergoing cyto-reductive and major abdominal surgery. In addition the effect of prewarming on intra and postoperative body core temperature will be evaluated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard | No Intervention | Study arm in which patients are treated according to standard operating procedures. Acting as "control arm". | |
| Standard + Microdialysis | Experimental | Study arm in which patients are treated according to standard operating procedures but also receive Microdialysis through a small catheter which is inserted into subcutaneous upper arm fatty tissue. |
|
| Prewarm | Experimental | Study arm in which patients are treated according to standard operating procedures plus prewarming period of at least 30 minutes during induction of combined general and epidural anesthesia. |
|
| Prewarm + Microdialysis | Experimental | Study arm in which patients are treated according to standard operating procedures plus prewarming period of at least 30 minutes during induction of combined general and epidural anesthesia and Microdialysis through a small catheter which is inserted into subcutaneous upper arm fatty tissue |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Prewarming | Other | Patients are treated according to standard operating procedures plus prewarming period of at least 30 minutes during induction of combined general and epidural anesthesia. |
| Measure | Description | Time Frame |
|---|---|---|
| body core temperature drop from induction of anesthesia to start of surgery | approximately 30-40 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| body core temperature at the end of surgery | duration of surgery |
| Measure | Description | Time Frame |
|---|---|---|
| prolonged need for ventilatory support | Goal is to determine whether discrepancies between the different groups regarding prolonged postoperative need for ventilatory support.Defined through length of ventilation after surgery (hours) | 10 days postoperative |
| Changes in Microcirculation |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Michael Sander | Contact | 030450531-012 | -052 | michael.sander@charite.de |
| Name | Affiliation | Role |
|---|---|---|
| Michael Sander | Department of Anesthesiology and Intensive Care Medicine Campus Charité Mitte / Campus Virchow-Klinikum Berlin | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology and Intensive Care Medicine Campus Charité Mitte / Campus Virchow-Klinikum | Recruiting | Berlin | State of Berlin | 13353 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31438849 | Derived | Kaufner L, Niggemann P, Baum T, Casu S, Sehouli J, Bietenbeck A, Boschmann M, Spies CD, Henkelmann A, von Heymann C. Impact of brief prewarming on anesthesia-related core-temperature drop, hemodynamics, microperfusion and postoperative ventilation in cytoreductive surgery of ovarian cancer: a randomized trial. BMC Anesthesiol. 2019 Aug 22;19(1):161. doi: 10.1186/s12871-019-0828-1. |
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| Microdialysis | Device | 71 High Cut-Off Brain MD Catheter Membrane cut-off: 100 kDa Membrane length 30 mm Shaft length: 60 mm Dialysis AB, Stockholm, Sweden |
|
Goal is to determine whether the prewarming and hypothetically improved perioperative warming results in increased microcirculation determined through microdialysis.Measured in lactate/pyruvate (µmol/L) ratio |
| duration of surgery |
| ID | Term |
|---|---|
| D007035 | Hypothermia |
| ID | Term |
|---|---|
| D001832 | Body Temperature Changes |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D017551 | Microdialysis |
| ID | Term |
|---|---|
| D003956 | Dialysis |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
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