Corneal Protect Used During Cataract Surgery

Influence of 2% HPMC Used During Cataract Surgery for Intraoperative Corneal Optical Clarity and Post-operation Xerophthalmia.

This randomized controlled subject- and examiner-masked study comprised patients scheduled for cataract surgery.The patients will be randomly assigned to receive either balanced salt solution（BSS）or hydroxypropyl methylcellulose（HPMC）2% gel （Cornea Protect）.Each subject should undertake examination including - rupture time (TBUT), height of the river of tears, fluorescence staining, Schirmer Ⅰ test, ocular surface disease index (OSDI) and self-conscious symptom assessment questionnaire for assessment.

This randomized controlled subject- and examiner-masked study comprised patients scheduled for cataract surgery.Over 100 patients will be randomly assigned to receive either balanced salt solution（BSS）or hydroxypropyl methylcellulose（HPMC）2% gel （Cornea Protect）.Each subject will accept 5 times assessments:the day before surgery, surgery day , the day after surgery,a week after surgery and a month after surgery.Each time a subject should undertake examination including - rupture time (TBUT), height of the river of tears, fluorescence staining, Schirmer Ⅰ test, ocular surface disease index (OSDI) and self-conscious symptom assessment questionnaire et.al.The purpose is to evaluate the effect of Cornea Protect to maintain intraoperative clarity and to prevent the postoperative xerophthalmia.

Inclusion Criteria:

• with cataracts;
• aged 40 to 85 years old, gender not limited;
• plans to accept PHACO and intraocular lens(IOL)implantation surgery
• the lens nucleus hardness level is less than 3 ;
• signed informed consent.

Exclusion Criteria:

• allergic to any of the drugs or device in this study ；
• existence of other infectious diseases or allergic conjunctivitis.
• the eye had been chemical burned or thermal burned
• diagnosed as Stevens Johnson syndrome or eye-pemphigoid.
• diagnosed with glaucoma or high intraocular pressure;
• existence of eyelid and lacrimal duct disease;
• received any eye surgery in 3 months;
• wearing corneal contact lens;
• history suggests there are serious heart, lung, liver or renal function disorder;
• pregnancy or lactation women;
• Other conditions considered not appropriate by the investigators.