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This is a phase II, single center, open-label, non randomized clinical study to assess the uptake, safety and tolerability of Imatinib in acute Cervical Spinal Cord Injury patients. The aim is to determine if Imatinib reaches sufficient blood levels when given to patients with cervical spinal cord injury, via a gastric feeding tube, and also evaluate the safety and tolerability of this drug treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Imatinib | Experimental | Day 1. 800 mg, Day 2-14: 2 * 400 mg per day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Imatinib | Drug | Day 1. 800 mg, Day 2-14: 2 * 400 mg per day |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in levels of Imatinib in plasma and cytokines in serum day 1-3, 7, 10, 14, 16, 19 | Day 1-3, 7, 10, 14, 16, 19 |
| Measure | Description | Time Frame |
|---|---|---|
| Adverse events | Day 1-19 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mikael Svensson, Prof.MD.PhD | Contact | +46- (0)8-517 716 95 | mikael.a.svensson@karolinska.se |
| Name | Affiliation | Role |
|---|---|---|
| Mikael Svensson, Prof.MD.PhD | Karolinska University Hospital | Principal Investigator |
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| ID | Term |
|---|---|
| D000068877 | Imatinib Mesylate |
| ID | Term |
|---|---|
| D001549 | Benzamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D001565 | Benzoates |
| D000146 |
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| Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D010879 | Piperazines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D011743 | Pyrimidines |