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Bleeding after redo cardiac surgery is a common, unresolved and consequences-heavy event as per present day. Tisseel (Baxter inc) sprayed on the already hemostased mediastinum jut before closing seems a promising technique to radically diminish bleeding.
This study aims to verify this efficacy volume in chest drains) and possibly the consensual blood transfusion lessening.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TISSEEL | Experimental | Spray Fibrin Sealant |
|
| CONTROL | Active Comparator | Traditional hemostasis and chest closure routine |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Spray Fibrin Sealant | Procedure | Baxter Tisseel (Fibrin Sealant) is sprayed in the mediastinum at the end of the operation afetr routine chest hemostasis protocol has been completed, right before closing the chest. |
| Measure | Description | Time Frame |
|---|---|---|
| Bleeding (Amount of blood (ml) collected in chest drainage) | Amount of blood (ml) collected in chest drainage in the first 24 hours after operation | first 24 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Allogeneic blood Sparing (Amount of Allogeneic Blood units (number) transfused in the first 4 days after surgery) | Amount of Allogeneic Blood units (number) transfused in the first 4 days after surgery | 4 days after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| European Hospital | Rome | Lazio | 00149 | Italy |
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| ID | Term |
|---|---|
| D006470 | Hemorrhage |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D015718 | Fibrin Tissue Adhesive |
| ID | Term |
|---|---|
| D005337 | Fibrin |
| D001798 | Blood Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
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|
| Traditional Hemostasis and chest Closure Routine | Procedure | Routine chest hemostasis and closure protocol (gauzes and inspection till satisfactory according to the surgeon) |
|