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This is a comparison of clinical outcomes between a pre-hospital and an in-hospital thrombolysis patient registry.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pre-hospital thrombolysis | Patients with acute ischemic stroke who are cared in a specialized STroke Emergency MObile (STEMO) before admission to the Hospital and receive thrombolytic therapy (either in STEMO or in Hospital). |
| |
| In-hospital thrombolysis | Patients with acute ischemic stroke who receive thrombolytic therapy after admission to an University Hospital. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| thrombolysis in a pre-hospital setting (STEMO concept) | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| modified Rankin Scale (mRS) score | dichotomized mRS 0-1 and 2-6 in patients who lived at home without assistance prior to the index stroke. | three months after event |
| Measure | Description | Time Frame |
|---|---|---|
| modified Rankin Scale (mRS) score | dichotomized mRS 1-3 and 4-6 | three months after event |
| modified Rankin Scale (mRS) score | mortality (mRS=6) |
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Inclusion Criteria:
Exclusion Criteria:
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acute ischemic stroke patients with thrombolytic treatment
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| Name | Affiliation | Role |
|---|---|---|
| Heinrich J Audebert, MD | Center for Stroke Research Berlin, Charité Universitätsmedizin Berlin | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charité | Berlin | State of Berlin | 10117 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24756512 | Background | Ebinger M, Winter B, Wendt M, Weber JE, Waldschmidt C, Rozanski M, Kunz A, Koch P, Kellner PA, Gierhake D, Villringer K, Fiebach JB, Grittner U, Hartmann A, Mackert BM, Endres M, Audebert HJ; STEMO Consortium. Effect of the use of ambulance-based thrombolysis on time to thrombolysis in acute ischemic stroke: a randomized clinical trial. JAMA. 2014 Apr 23-30;311(16):1622-31. doi: 10.1001/jama.2014.2850. | |
| 27430529 |
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| ID | Term |
|---|---|
| D000083242 | Ischemic Stroke |
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D005343 | Fibrinolytic Agents |
| ID | Term |
|---|---|
| D050299 | Fibrin Modulating Agents |
| D045504 | Molecular Mechanisms of Pharmacological Action |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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| three months after event |
| modified Rankin Scale (mRS) score | ordinal analysis across whole mRS range | three months after event |
| Background |
| Kunz A, Ebinger M, Geisler F, Rozanski M, Waldschmidt C, Weber JE, Wendt M, Winter B, Zieschang K, Fiebach JB, Villringer K, Erdur H, Scheitz JF, Tutuncu S, Bollweg K, Grittner U, Kaczmarek S, Endres M, Nolte CH, Audebert HJ. Functional outcomes of pre-hospital thrombolysis in a mobile stroke treatment unit compared with conventional care: an observational registry study. Lancet Neurol. 2016 Sep;15(10):1035-43. doi: 10.1016/S1474-4422(16)30129-6. Epub 2016 Jul 16. |
| 29459395 | Derived | Nolte CH, Ebinger M, Scheitz JF, Kunz A, Erdur H, Geisler F, Braemswig TB, Rozanski M, Weber JE, Wendt M, Zieschang K, Fiebach JB, Villringer K, Grittner U, Kaczmarek S, Endres M, Audebert HJ. Effects of Prehospital Thrombolysis in Stroke Patients With Prestroke Dependency. Stroke. 2018 Mar;49(3):646-651. doi: 10.1161/STROKEAHA.117.019060. Epub 2018 Feb 19. |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D002317 | Cardiovascular Agents |
| D045506 | Therapeutic Uses |
| D006401 | Hematologic Agents |