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The purpose of this study is to compare nifedipine controlled-release (CR) tablets (Xin Ran) with nifedipine controlled-release tablets (Adalat)in the treatment of Early Morning Blood Pressure and Central Arterial Pressure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| nifedipine CR tablets (Xin Ran) | Experimental | Subjects will take a nifedipine controlled-release tablet (30 mg, Xin Ran) orally in every morning for a 8-week treatment period. |
|
| nifedipine CR tablets (Adalat) | Active Comparator | Subjects will take a nifedipine controlled-release tablet (30 mg, Adalat) orally in every morning for a 8-week treatment period. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| nifedipine CR tablets (Xin Ran) | Drug |
| ||
| Adalat |
| Measure | Description | Time Frame |
|---|---|---|
| change in the average of early morning blood pressure mean systolic and diastolic pressure from baseline | early morning blood pressure mean systolic and diastolic pressure measured by Omron-7080-IC calculated as the mean of all of the early morning blood pressure mean systolic and diastolic pressure measurements for 7 consecutive days after 8 weeks. | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| change in central systolic blood pressure from baseline . | 8 weeks | |
| change in central diastolic blood pressure from baseline . | 8 weeks | |
| change in central pulse pressure from baseline . |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chongping Liu | Contact | (86)21-62102186 |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ruijin Hospital Affiliated to Shanghai Jiao Tong University Medical School | Recruiting | Shanghai | China |
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| Drug |
|
| 8 weeks |
| change in augmentation index from baseline . | 8 weeks |
| change in mean systolic and diastolic pressure from baseline | 8 weeks |
| ID | Term |
|---|---|
| D000075222 | Essential Hypertension |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D009543 | Nifedipine |
| ID | Term |
|---|---|
| D004095 | Dihydropyridines |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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