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Difficulty to recruit all the patients
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The aim of this study is to understand why the regeneration of the cutaneous sensory nerve fibers is poor in post-burn scar.
The presence or the lack of several molecular factors known to regulate neuronal cell development will be evaluate and compared within biopsies from healthy skin and post-burn scar.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Skin biopsy | Other | On the same patient, a biopsy of post-burn scar is removed. A second one is removed from healthy skin. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Skin biopsy | Procedure | 2 biopsies are done on the same patient : 20 cutaneous biopsies from post-burn scar and from healthy skin |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of the differences of expression of genes coding for regulating proteins of the innervation | To evaluate the differences of expression of genes coding for regulating proteins of the innervation on samples of healthy skins and post-burn scar. These biopsies will be removed from post-burn patients (at least one year after burn) and allowing the comparison between conflicting dermatomes: a healthy dermatome and a formerly burned dermatome | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Validation of the difference of density of intra-epidermic nerve fibers | To validate the existence of a difference of density of intra-epidermal nerve fibers between the healthy skins and the post-burn scar. | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Laurent MISERY | CHRU de Brest | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU de Brest | Brest | France | 29609 | France |
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