Single Ascending Dose Study of MYK-461 in Healthy Volunteers

Safety, Tolerability, Preliminary Pharmacokinetics and Pharmacodynamics of Single Ascending Oral Doses of MYK-461 in Healthy Volunteers

The purpose of this study is to establish initial safety, tolerability, pharmacokinetics and pharmacodynamics of MYK-461 in human subjects. This is a randomized, double-blind, placebo-controlled, sequential group, single ascending (oral) dose study in healthy volunteers aged 18-55 years.

Inclusion Criteria:

• Normal body mass index (BMI)
• Normal LVEF
• Normal electrocardiogram (ECG)
• Females must not be breastfeeding and must be permanently sterilized or are postmenopausal.

Exclusion Criteria:

• Any structural abnormalities on echocardiography
• Positive results of HIV test and/or seropositive for HCV or HBV.