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| ID | Type | Description | Link |
|---|---|---|---|
| 2013-A01043-42 | Other Identifier | ANSM |
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| Name | Class |
|---|---|
| Institut de Recherche Pierre Fabre | OTHER |
| Hospital Avicenne | OTHER |
| Adeprina | OTHER |
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The purpose of this study is to determine whether oral supplementation with one form of arginine improves vascular endothelial function in healthy subjects with risk factors associated with the metabolic syndrome
The study is a randomized crossover study including 32 subjects with risk factors associated with metabolic syndrome. In a cross-over design, each subject received oral arginine and placebo, in a randomized order, and were studied the day preceding the first day of administration of arginine (or placebo) and after 4 weeks of arginine (or placebo) supplementation. The two periods of supplementation were separated by a washout period of at least 4 weeks.
The subject were studied in the morning (when before supplementation) and in a whole day (when after supplementation).
The mornings cessions consisted of fasting blood draw and vascular explorations, including a measurement of endothelium-dependent brachial artery reactivity ("Flow mediated dilation"), directly coupled to a measurement of post-ischemic digital reactivity (with the Endo-PAT method), completed by a measurement of non-endothelium-dependent brachial artery reactivity. An analysis of the pulse wave geometry was also performed.
The whole-day cession consisted of the same fasting vascular explorations. Blood tests were performed fasting and repeated 2, 4 and 6 h after ingestion of a high-fat meal (900 kcal). Measurements of Flow mediated dilation was repeated 4h and postischemic digital reactivity were repeated 2, 4 and 6 h after ingestion of the high fat meal.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy subjects with 'hypertriglyceridemic waist' | Experimental | Subjects with overweight, elevated waist circumference and elevated fasting triglyceridemia. Intervention: see below |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| One form of arginine | Dietary Supplement | 3 capsules containing 0.5g of one form of L-arginine (1.5g) 3 times daily (4.5g per day) for 1 month |
|
| Measure | Description | Time Frame |
|---|---|---|
| Physiological assessment of endothelial function in postprandial and fasting (Endothelial function was assessed by flow-mediated dilation (FMD) and peripheral arterial tonometry (EndoPAT) | Endothelial function was assessed by flow-mediated dilation (FMD) and peripheral arterial tonometry (EndoPAT). FMD technique was used during the fasting test. The RHI measurements were performed the morning fasting and 2, 4, and 6 hours after administration of the high-fat meal, in the case of exploration days after supplementation. In terms of the 4h measurement, it was coupled to a FMD assessment. FMD was calculated as the percentage change in artery diameter at peak dilation compared with baseline and is reported as a percentage. The Reactive Hyperemia Index (RHI) was calculated as the ratio of the average pulse wave amplitude during hyperemia (60 to 120 s of the postocclusion period) to the average pulse wave amplitude during baseline in the occluded hand divided by the same values in the control hand and then multiplied by a baseline correction factor. | Before the supplementation at day 0 and after the supplementation (1month after) at day 29 for each treatment |
| Evaluation of plasma vascular cell adhesion molecule-1 (VCAM-1) of endothelial function in postprandial and fasting | Fasting plasma concentrations of VCAM-1 will be determined using two custom mixed assay kits with antibody-coated beads using the Luminex xMAP technology platform for multiplexing of immunochemical bioassays. | Before the supplementation at day 0 and after the supplementation (1month after) at day 29 for each treatment |
| Evaluation of plasma intercellular adhesion molecule (ICAM-1) of endothelial function in postprandial and fasting | Fasting plasma concentrations of ICAM-1 will be determined using two custom mixed assay kits with antibody-coated beads using the Luminex xMAP technology platform for multiplexing of immunochemical bioassays. | Before the supplementation at day 0 and after the supplementation (1month after) at day 29 for each treatment |
| Evaluation of plasma E-Selectin of endothelial function in postprandial and fasting |
| Measure | Description | Time Frame |
|---|---|---|
| Asymmetric Dimethyl-L-Arginine (ADMA) measurement | - Fasting ADMA concentrations were measured by an enzyme-linked immunosorbent assay. | Before the supplementation at day 0 and after the supplementation (1month after) at day 29 for each treatment |
| Amino acids measurement |
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Inclusion Criteria :
Exclusion Criteria :
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| Name | Affiliation | Role |
|---|---|---|
| Robert Benamouzig | Hospital Avicenne | Principal Investigator |
| François Mariotti, PhD | AgroParisTech | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre de Recherche sur Volontaires (CRV), Hospital Avicenne | Bobigny | ÃŽle-de-France Region | 93000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12660684 | Background | Abdelhamed AI, Reis SE, Sane DC, Brosnihan KB, Preli RB, Herrington DM. No effect of an L-arginine-enriched medical food (HeartBars) on endothelial function and platelet aggregation in subjects with hypercholesterolemia. Am Heart J. 2003 Mar;145(3):E15. doi: 10.1067/mhj.2003.160. | |
| 7560599 | Background | Adams MR, Forsyth CJ, Jessup W, Robinson J, Celermajer DS. Oral L-arginine inhibits platelet aggregation but does not enhance endothelium-dependent dilation in healthy young men. J Am Coll Cardiol. 1995 Oct;26(4):1054-61. doi: 10.1016/0735-1097(95)00257-9. |
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| ID | Term |
|---|---|
| D050177 | Overweight |
| D064250 | Hypertriglyceridemic Waist |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| placebo | Dietary Supplement | 3 capsules containing 0.5g cellulose (non active product) 3 times daily (4.5g per day) for 1 month |
|
Fasting plasma concentrations E-Selectin will be determined using two custom mixed assay kits with antibody-coated beads using the Luminex xMAP technology platform for multiplexing of immunochemical bioassays. |
| Before the supplementation at day 0 and after the supplementation (1month after) at day 29 for each treatment |
| Evaluation of plasma P-Selectin of endothelial function in postprandial and fasting | Fasting plasma concentrations P-Selectin will be determined using two custom mixed assay kits with antibody-coated beads using the Luminex xMAP technology platform for multiplexing of immunochemical bioassays. | Before the supplementation at day 0 and after the supplementation (1month after) at day 29 for each treatment |
| Evaluation of plasma Plasminogen activator inhibitor-1 (PAI-1) of endothelial function in postprandial and fasting | Fasting plasma concentrations of PAI-1) will be determined using two custom mixed assay kits with antibody-coated beads using the Luminex xMAP technology platform for multiplexing of immunochemical bioassays. | Before the supplementation at day 0 and after the supplementation (1month after) at day 29 for each treatment |
| Evaluation of plasma C-reactive protein (CRP) of endothelial function in postprandial and fasting | Fasting plasma concentrations of CRP will be determined using two custom mixed assay kits with antibody-coated beads using the Luminex xMAP technology platform for multiplexing of immunochemical bioassays. | Before the supplementation at day 0 and after the supplementation (1month after) at day 29 for each treatment |
| Evaluation of plasma Endothelin-1 of endothelial function in postprandial and fasting | Fasting plasma concentrations of Endothelin-1 will be determined using two custom mixed assay kits with antibody-coated beads using the Luminex xMAP technology platform for multiplexing of immunochemical bioassays. | Before the supplementation at day 0 and after the supplementation (1month after) at day 29 for each treatment |
Fasting amino acids contents was assayed by High-performance liquid chromatography (HPLC). |
| Before the supplementation at day 0 and after the supplementation (1month after) at day 29 for each treatment |
| Nitrite measurement | Fasting nitrite were analyzed by Gas chromatography-mass spectrometry (GC-MS). | Before the supplementation at day 0 and after the supplementation (1month after) at day 29 for each treatment |
| Complete blood count (CBC) analysis | Fasting and postprandial complete blood count (CBC) (was assayed using "classical clinical biochemical analyzers". | Before the supplementation at day 0 and after the supplementation (1month after) at day 29 for each treatment |
| Insulin and glucose measurement | The fasting insulin and the fasting and postprandial glucose were assayed using "classical clinical biochemical analyzers". | Before the supplementation at day 0 and after the supplementation (1month after) at day 29 for each treatment |
| Lipid profile analysis | - The fasting lipid profile (triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol) and the postprandial evolution of triglycerides were measured and were assayed using "classical clinical biochemical analyzers". | Before the supplementation at day 0 and after the supplementation (1month after) at day 29 for each treatment |
| Metabolomic analysis | Fasting metabolomic analysis with metabolomic approaches | Before the supplementation at day 0 and after the supplementation (1month after) at day 29 for each treatment |
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| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D015228 | Hypertriglyceridemia |
| D006949 | Hyperlipidemias |
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |