Dehydration is a major problem of high output stoma with a 17% rate of readmission at 30 days. Dehydratations are resulting of significant electrolyte loss: sodium, potassium and renal failure. Nowadays, there are no recommendations nor national nor international for high output ileostomy treatment. Apart from the anti-diarrhea treatments used in current practice, somatostatin analogs have proven efficacy in the literature. Theses analogs permit to decrease significantly gastrointestinal secretions. Several teams use these analogs in order to decrease the flow of highly productive ileostomy.

The aim of the study is to evaluate the efficacy first line treatment with lanreotide associated with current anti-diarrheal treatment for patients with high output ileostomy (or greater throughput 1.5l / 24h) with or without associated dehydration

Inclusion Criteria:

• Legal at the time of signing the agreement
• Subject affiliated to the french social protection
• Ileostomy has achieved since 10 days minimum at day 0 (D0: start of study treatment)
• Ileostomy output > 1.5 liters / 24h for at least 24 hours at day 0
• accept to use an effective method of contraception during the study: (during the 6 months following injection of lanreotide for the experimental group and for the control group: 4 days after the last dose of chlorhydrate of loperamide
• People able to understand the objectives, modalities and risks related to the study and give written informed consent

Exclusion Criteria:

• people with guardianship or with judicial protection
• simultaneous participation in another biomedical research protocol involving a drug or topic exclusion period
• pregnancy or breastfeeding
• administration of lanreotide or related peptide between surgery and D0
• hypersensitivities to lanreotide or related peptides and / or diosmectite and / or loperamide and / or one of their excipients
• acute hemorrhagic colitis
• bloody diarrhea and / or high fever
• Clostridium Difficile Infection at the inclusion
• uncontrolled diabetis defined by HbA1c> 7% at D0