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TST (Triple stimulation technique) helps to better quantify the proportion of motor units activated by transcranial magnetic stimulation. The abnormal amplitude registered by TST is proportional to the intensity of conduction disorders. The evaluation of these disorders is more precise with this technique than with the slowing of the central conduction time (CCT).
The investigators propose to use this technique in CNS pathologies where this disorder is significant and essential, like multiple sclerosis and stroke.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stroke patients | Experimental | The patients will be submitted to a triple stimulation examination. |
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| Control Subjects | Active Comparator | This group of patients did not suffer from a stroke. They will also be submitted to a triple stimulation examination. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Triple stimulation technique | Procedure | Evoked motor potentials obtained by magnetic transcranial stimulation are usually used, in standard practice, to evaluate the corticospinal tract. This procedure combines two techniques: the magnetic stimulation and the electroneuromyography. It is based on the double collision principle between the descending central stimulation (magnetic) and the ascending peripheric stimulation, hereby suppressing the issue of desynchronisation of evoked motor potentials. The Triple stimulation technique allows a better quantification of the proportion of motor units activated by the transcranial stimulation. |
| Measure | Description | Time Frame |
|---|---|---|
| Amplitude of the motor evoked potentials | during the TST (30 min) | |
| Surface of the motor evoked potentials | during the TST (30 min) | |
| Amplitude ratio of the TST | during the TST (30 min) | |
| Surface ratio of the TST | during the TST (30 min) | |
| TMS threshold | during TST (30 min) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bernard Dachy, MD | CHU Brugmann | Principal Investigator |
| Andrey Bragin, MD | CHU Brugmann | Principal Investigator |
| Pedro Calderon, MD | CHU Brugmann | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Brugmann | Brussels | 1020 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 9549520 | Background | Magistris MR, Rosler KM, Truffert A, Myers JP. Transcranial stimulation excites virtually all motor neurons supplying the target muscle. A demonstration and a method improving the study of motor evoked potentials. Brain. 1998 Mar;121 ( Pt 3):437-50. doi: 10.1093/brain/121.3.437. | |
| 10071055 | Background | Magistris MR, Rosler KM, Truffert A, Landis T, Hess CW. A clinical study of motor evoked potentials using a triple stimulation technique. Brain. 1999 Feb;122 ( Pt 2):265-79. doi: 10.1093/brain/122.2.265. |
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