Serum MIF in Acute Kidney Injury | NCT02352506

Studies
Serum MIF in Acute Kidney Injury

NCT02352506

Sponsor

Medical University of Vienna

Status

Completed

Last Update Posted

Mar 15, 2023Actual

Enrollment

500Actual

Phase

Not provided

Conditions

Acute Kidney Injury

Interventions

Blood draw for measurement of MIF

Countries

Austria

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Mar 2023

Overall Recruitment Status or Expanded Access Status

Completed

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Jan 2015Actual

Primary Completion Date

Nov 2019Actual

Completion Date

Jan 2023Actual

First Submitted Date

Jan 28, 2015

First Submission Date that Met QC Criteria

Jan 28, 2015

First Posted Date

Feb 2, 2015Estimated

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Mar 13, 2023

Last Update Posted Date

Mar 15, 2023Actual

Description Module

Brief Summary

Acute kidney injury (AKI) is a common complication in critical care patients. Currently no parameters are available for early prognosis of AKI. Macrophage migration inhibitory factor (MIF) has been associated with AKI in clinical studies. The aim of this study is to evaluate the time course of MIF concentrations in patients with AKI.

Detailed Description

Not provided

Design Module

Study Type

Observational

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Target Follow-Up Duration

Not provided

Phases

Not provided

Interventional Study Design

Allocation

Not provided

Intervention Model

Biospecimen

Retention

Enrollment

500Actual

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
AKI		Patients developing AKI during the ICU stay	Other: Blood draw for measurement of MIF
No AKI		Matched controls not developing AKI during the ICU stay	Other: Blood draw for measurement of MIF

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Blood draw for measurement of MIF	Other	Observational study, no intervention	AKI No AKI

Measure	Description	Time Frame
Macrophage migration inhibitory factor		Up to 14 days

Measure	Description	Time Frame
Serum creatinine		Up to 14 days

Eligibility Module

Eligibility Criteria

Exclusion Criteria:

Age < 18 years and > 80 years
Patients with chronic dialysis
Patients with continuous hemodialysis, hemofiltration or hemodiafiltration within 4 weeks prior to the study
Patients with an expected length of ICU stay shorter than 3 days
Patients with a low probability of surviving the first 2 days after ICU admission
Pregnancy and nursing

Accepts Healthy Volunteers

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

80 Years

Standard Ages

AdultOlder Adult

Study Population

Critical care patients

Sampling Method

Non-Probability Sample

Contacts/Locations Module

Central Contacts

Not provided

Overall Officials

Not provided

Locations

Facility	Status	City	State	ZIP	Country	Contacts
Medical University of Vienna		Vienna		1090	Austria

Condition Browse Module

MeSH Terms

ID	Term
D058186	Acute Kidney Injury

Ancestor Terms

ID	Term
D051437	Renal Insufficiency
D007674	Kidney Diseases
D014570	Urologic Diseases
D052776	Female Urogenital Diseases

Browse Leaves

Not provided

Browse Branches

Not provided

Intervention Browse Module

MeSH Terms

ID	Term
D001800	Blood Specimen Collection

Ancestor Terms

ID	Term
D013048	Specimen Handling
D019411	Clinical Laboratory Techniques
D019937	Diagnostic Techniques and Procedures
D003933	Diagnosis

Browse Leaves

Not provided

Browse Branches

Not provided