A randomized placebo-controlled clinical trial investigating the effects of Liraglutide as an add-on to intensive insulin therapy in overweight insulin pump treated type 1 diabetes patients in suboptimal glycemic control.

Inclusion Criteria:

• Type 1 diabetes ≥ 1 year
• BMI > 25 kg/m2
• Insulin pump ≥ 1 year
• HbA1c > 58 mmol/mol
• Use of carbohydrate counting and the insulin pump bolus calculator

Exclusion Criteria:

• Gastroparesis
• Impaired renal function (eGFR < 60 ml/min/1.73m2)
• Liver disease with ALAT > 2.5 times the upper limit of the reference interval
• Acute or chronic pancreatitis or history of chronic pancreatitis or idiopathic acute pancreatitis
• Inflammatory bowel disease
• History of cancer (except basal cell skin cancer) which in the investigators opinion could interfere with the results of the trial, or cancer during the past 5 years
• Thyroid adenoma
• Subjects with personal or family history of MTC or MEN2
• Use of anti-diabetic medicine (other than insulin), corticosteroids or other drugs affecting glucose metabolism during the study period or within 30 days prior to study start
• Known or suspected alcohol or drug abuse
• Other concomitant medical or psychological condition that according to the investigator's assessment makes the patient unsuitable for study participation
• Females of childbearing potential who are pregnant, breast-feeding or intend to become pregnant or are not using adequate contraceptive methods.
• Simultaneous participation in any other clinical intervention trial
• Known or suspected hypersensitivity to Liraglutide
• Inability to understand the patient information and to give informed consent
• Acute treatment required proliferative retinopathy or maculopathy (macular oedema)
• Any Cardiac disorder which in the investigators opinion could interfere with the safety and results of the trial.