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| Name | Class |
|---|---|
| Biomathics | UNKNOWN |
The main objective of the GOOD initiative was to determine which spatio-temporal gait parameters and/or combination(s) of spatio-temporal gait parameters best differentiate between cognitively healthy individuals (CHI), patients with mild cognitive impairment (MCI) and those with mild and moderate dementia.
Gait disorders are frequent in individuals with cognitive disorders. However, the profile of spatio-temporal gait parameters in the different cognitive status in aging (from normal cognition to dementia) has been poorly studied. Determining this profile associated with the severity of cognitive disorders may be helpful to understand the complex interplay between gait and cognitive disorders and, thus, may have important implication for the diagnosis process of patients with and without dementia. For instance, defining a motor phenotype of the severity of cognitive disorders by using quantitative gait measurements could be used to improve the prediction and the diagnosis of dementia.
The investigators hypothesized that, compared to CHI, people with MCI and mild dementia could be characterized by specific phenotypes of spatio-temporal gait parameters measured with the GAITRite® system, and that these profiles could be explained by declines in domain-specific cognitive performance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cognitively healthy individuals (CHI) | CHI were participants without objective cognitive impairment |
| |
| mild cognitive impairment (MCI) | MCI was diagnosed if participants met the following criteria: presence of spontaneous cognitive complaints and objective cognitive impairment |
| |
| mild and moderate dementia | Diagnoses of dementia were assigned according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV TR, 2000; Association, 2000; 22) at consensus diagnostic case conferences |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| gait and cognitive testing | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Spatio-temporal gait parameters | Spatio-temporal gait parameters were measured at steady state walking using GAITRite®-system. | This outcome is assessed at inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical assessment | This outcome was assessed by a questionnaire. | This outcome is assessed at inclusion |
| Cognitive status | Cognitive status was assessed by cognitive testing. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients were recruited in each memory clinic by a physician
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Olivier Beauchet, MD, PhD | Contact | ++33 2 41 35 57 38 | olbeauchet@chu-angers.fr |
| Name | Affiliation | Role |
|---|---|---|
| Olivier Beauchet, MD, PhD | University Hospital, Angers | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | Recruiting | Angers | 49933 | France |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D005684 | Gait |
| D009483 | Neuropsychological Tests |
| ID | Term |
|---|---|
| D010808 | Physical Examination |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D016138 | Walking |
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| This outcome is assessed at inclusion |
| D008124 |
| Locomotion |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |