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PCR for chlamydia DNA is done in paraffin blocks of cases of primary tubal cancer and is compared to cases of high grade serous ovarian cancer and normal tubes .
The investigators shall review the early cancer detection unite pathology records for the past 10 years , for cases diagnosed with primary Fallopian tube cancers , cases of high and low grade serous ovarian cancer and cases underwent hysterectomy and salpingectomy for non oncological reasons. Paraffin blocks for suitable selected patients will be examined histologically to confirm the primary diagnosis . Chlamydia DNA in these paraffin blocks of the Fallopian tubes and ovarian tissues will be examined using PCR techniques . The possible correlation between the presence of Chlamydia DNA and the ovarian serous tumours and primary tubal cancer will be analyzed statistically .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| primary tubal cancer group | Paraffin blocks of cases of primary tubal cancer |
| |
| high grade serous ovarian cancer group | Paraffin blocks of cases of high grade serous ovarian cancer |
| |
| Low Grade Serous Ovarian Cancer | Paraffin blocks of cases of low grade serous ovarian cancer |
| |
| normal tubes group | Paraffin blocks of tubes of hysterectomies due to non-oncologic causes |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PCR for chlamydia DNA in primary tubal cancer | Other | PCR for presence of chlamydia DNA in paraffin blocks retrieved for tubal and ovarian tissues in all groups |
|
| Measure | Description | Time Frame |
|---|---|---|
| Presence of chlamydia DNA in tubal and ovarian tissues | Up to 24 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Presence of concomitant tubal cancer with high grade serous ovarian cancer | Up to 8 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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Pathology blocks of patients with primary tubal cancer and with high grade serous ovarian cancer and normal tubes.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams Maternity Hospital | Cairo | Egypt |
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| ID | Term |
|---|---|
| D005185 | Fallopian Tube Neoplasms |
| D010051 | Ovarian Neoplasms |
| ID | Term |
|---|---|
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D016133 | Polymerase Chain Reaction |
| ID | Term |
|---|---|
| D021141 | Nucleic Acid Amplification Techniques |
| D005821 | Genetic Techniques |
| D008919 | Investigative Techniques |
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Archival Paraffin blocks for cases of primary tubal cancers , high grade serous ovarian cancers , low grade serous ovarian cancers and normal Fallopian tubes removed during Hysterectomy operations for benign Gynecological indications
| D005184 |
| Fallopian Tube Diseases |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D004701 | Endocrine Gland Neoplasms |
| D010049 | Ovarian Diseases |
| D004700 | Endocrine System Diseases |
| D006058 | Gonadal Disorders |