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| Name | Class |
|---|---|
| Lund University | OTHER |
The purpose of this study is to evaluate the ability of a blend of berries and probiotics in reducing low-grade inflammation and intestinal permeability in the elderly. The intervention period is one month. Blood and fecal samples will be collected for analysis at baseline and at the end of the intervention with the aim to analyse possible changes in different parameters at the two timepoints. The participants will also be asked to keep a study diary throughout the study period for the documentation of their intestinal health and as a means for checking compliance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Powder consisting of maltodextrine, treated to resemble the Active product in appearance and taste. |
|
| Active, only probiotics | Active Comparator | Powder consisting of freezedried bacteria at 10 billions cfu/daily dose and maltodextrine, treated to resemble the Active product in appearance and taste. |
|
| Active, blend of berries and probiotics | Active Comparator | Powder consisting of freezedried berries , probiotics at 10 billions cfu/daily dose and maltodextrine. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Dietary Supplement | Powder |
| |
| Active, only probiotics |
| Measure | Description | Time Frame |
|---|---|---|
| Reduced intestinal permebility measured as decline in the levels of zonulin in blood samples | All blood markers analysed in the study will be measured at start, before the onset of intervention and 4 weeks later at the end of intervention. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Lund University | Malmö | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38896223 | Derived | Lazou-Ahren I, Bjorklund M, Molin G, Xu J, Onning G, Elmstahl S, Jeppsson B. Probiotic-Reduced Inflammaging in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Probiotics Antimicrob Proteins. 2025 Oct;17(5):3429-3439. doi: 10.1007/s12602-024-10310-7. Epub 2024 Jun 19. |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| D019936 | Probiotics |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Dietary Supplement |
Powder |
|
| Active, blend of berries and probiotics | Dietary Supplement | Powder |
|
| D019587 | Dietary Supplements |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |