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Objective: To investigate the correlation between total and bioavailable serum 25-OH vitamin D, ovarian reserve and ovarian response to controlled stimulation in egg donors.
Design: Retrospective study. Setting: University affiliated private IVF center. Intervention: Serum analysis of vitamin D, bioavailable vitamin D, antimullerian hormone (AMH), antral follicular count (AFC), reproductive outcome of oocytes recipients Main outcome measure: AMH, AFC, number of oocytes retrieved and number of mature oocytes, pregnancy and implantation rate of donated oocytes'recipients.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| vitamin D,AMH, AFC, reproductive outcome egg recipients | Other | observational study of 269 donnors |
| Measure | Description | Time Frame |
|---|---|---|
| Numbers of oocytes retrieved | 2 months |
| Measure | Description | Time Frame |
|---|---|---|
| implantation rate | 2 months | |
| pregnancy rate | 2 months | |
| AFC |
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Inclusion Criteria:
Exclusion Criteria:
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oocytes' donors who underwent ovarian stimulation cycles in our clinic from June 2013 to April 2014
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| Name | Affiliation | Role |
|---|---|---|
| Juan Antonio GarcĂa Velasco, Professor | IVI Madrid | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Result | Holick MF et al. Endocrine Society. Evaluation, treatment, prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911-1930 Rudick B et al. Characterizing the influence of vitamin D levels on IVF outcomes. Hum Reprod. 2012;27:3321-7 Polyzos NP et al. Vitamin D deficiency and pregnancy rates in women undergoing single embryo, blastocyst stage, transfer (SET) for IVF/ICSI. Hum Reprod. 2014;29:2032-40 Franasiak JM et al. Vitamin D levels do not affect IVF outcomes following the transfer of euploid blastocysts. Am J Obstet Gynecol 2014;211:x.ex-x.ex Fabris A, Pacheco A, Cruz M, Puente JM, Fatemi H, Garcia-Velasco JA. Impact of circulating levels of total and bioavailable serum vitamin D on pregnancy rate in egg donation recipients. Fertil Steril. 2014. Irani M, Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil Steril. 2014 ;102:460-468 |
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| 2 months |
| number of mature oocytes | 2 months |
| AMH | 2 months |