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| ID | Type | Description | Link |
|---|---|---|---|
| 81371142 | Other Grant/Funding Number | National Natural Science Foundation of China | |
| 20120633B14 | Other Grant/Funding Number | Hangzhou Science and Technology Project |
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| Name | Class |
|---|---|
| Hangzhou Occupational Disease Prevention Hospital | OTHER |
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Analysis different measures preventive effect on carious Lesions incidence and oral microecological system change of preschool children
Different caries prevention trials including fluoride vanish, IgY-passive immunotherapy and probiotics lasting 24 months were conducted with a total of 500 children aged 24 to 54 months of age in Lin'an, Zhejiang, China. The trials were cluster- domized .After obtaining parent´s informed consent, preschool children were clinical examinated according to ICDAS-Ⅱ and microbiological tested of saliva at baseline, 1m, 6m, 12m, 18m and 24m. To find the differences of caries incidence and oral microecology change in four groups, dmfs will be assessed and saliva will be analysed in experiment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | Only behavioral education for Caregiver | |
| fluoride varnish | Experimental | fluoride varnish every 6 months |
|
| ImmunoglobulinY | Experimental | anti-S.mutans Immunoglobulin yolk for everyday use |
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| Probiotics | Experimental | Probiotics use for 1 months |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fluoride varnish | Drug | Sodium fluoride 50mg/ml |
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| Measure | Description | Time Frame |
|---|---|---|
| The number of new cavitated or incipient carious lesion | To determine whether preschool children that only with caregiver behavior education have more new caries lesion than those taken some caries preventive measures by differences in dmfs（decay，missing，filling teeth surfaces） index after 24 months dental exams. | 24 months after first visit |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hui Chen | Department of Conservative Dentistry and Periodontics, Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University | Hangzhou | Zhejiang | 310006 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33381248 | Derived | Zhang J, Su L, Wang Y, Deng S. Improved High-Throughput Sequencing of the Human Oral Microbiome: From Illumina to PacBio. Can J Infect Dis Med Microbiol. 2020 Dec 11;2020:6678872. doi: 10.1155/2020/6678872. eCollection 2020. | |
| 31690590 | Derived | Wang Y, Wang S, Wu C, Chen X, Duan Z, Xu Q, Jiang W, Xu L, Wang T, Su L, Wang Y, Chen Y, Zhang J, Huang Y, Tong S, Zhou C, Deng S, Qin N. Oral Microbiome Alterations Associated with Early Childhood Caries Highlight the Importance of Carbohydrate Metabolic Activities. mSystems. 2019 Nov 5;4(6):e00450-19. doi: 10.1128/mSystems.00450-19. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Jan 24, 2017 | |
| Reset | Mar 13, 2017 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jan 24, 2017 | Mar 13, 2017 |
| ID | Term |
|---|---|
| D003731 | Dental Caries |
| ID | Term |
|---|---|
| D017001 | Tooth Demineralization |
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D019936 | Probiotics |
| ID | Term |
|---|---|
| D019587 | Dietary Supplements |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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| Immunoglobulin Yolk | Biological | anti-Streptococcus mutans IgY |
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| Probiotics | Dietary Supplement | 2g/day，Lactobacillus rhamnosus HN001, Bifidobacterium lactis Bi-07, Bifidobacterium lactis HN019, maltodextrin, fructose, skimmed milk powder |
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| D019602 |
| Food and Beverages |