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Randomized trial of supplying a cold vest as compared with controls (no cold vest) on cardiovascular risk factors such as blood lipids, insulin, blood pressure and body weight and also on basal metabolic rate. Recruitment of 100 participants and 70 are randomized to being given a vest which they can use to increase basal metabolic rate during 1-2 hours (as long as the pre-cooled vest stays cool) by activating brown adipose tissue and/or shivering. The remaining 30 subjects will constitute a control group. Lab tests and anthropometrics are checked at baseline, after 2 months and after 1 year.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cold vest | Experimental | Participants are given a cold vest that the pre-cool in a freezer. They are encouraged to use it daily to activate metabolism through brown adipose tissue and shivering. |
|
| control | No Intervention | No intervention, just recording of risk factors and basal metabolic rate. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cold vest | Other | The lowering of body temperature increases basal metabolic rate |
|
| Measure | Description | Time Frame |
|---|---|---|
| basal metabolic rate | basal metabolic rate measured in the fasting state by indirect calorimetry | up to 1 year |
| Composite measure of cardiovascular risk factors | Blood lipids, insulin, body weight, blood pressure | up to 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Fredrik H Nystrom, professor | Linkoeping University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Linkoping | Linköping | 58185 | Sweden |
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