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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
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The purpose of this study is to examine the effects of bile acids on GLP-1 secretion after Roux-en-Y gastric bypass.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Experimental | 150mL water |
|
| Ursodeoxycholic acid | Experimental | Ursodeoxycholic acid (750mg) dissolved in 150mL water |
|
| Chenodeoxycholic acid | Experimental | Chenodeoxycholic acid (1250mg) dissolved in 150mL water |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Water | Other |
| ||
| Ursodeoxycholic Acid |
| Measure | Description | Time Frame |
|---|---|---|
| GLP-1 secretion (evaluated by iAUC) | Baseline, 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120, 180 |
| Measure | Description | Time Frame |
|---|---|---|
| C-peptide secretion (evaluated by iAUC) | Baseline, 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120, 180 | |
| PYY secretion (evaluated by iAUC) | Baseline, 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120, 180 | |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hvidovre University Hospital | Hvidovre | DK-2650 | Denmark |
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| ID | Term |
|---|---|
| D009767 | Obesity, Morbid |
| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
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| ID | Term |
|---|---|
| D014867 | Water |
| D014580 | Ursodeoxycholic Acid |
| D002635 | Chenodeoxycholic Acid |
| ID | Term |
|---|---|
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D000838 | Anions |
| D007477 |
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|
| Chenodeoxycholic Acid | Drug |
|
| Glucagon secretion (evaluated by iAUC) |
| Baseline, 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120, 180 |
| GIP secretion (evaluated by iAUC) | Baseline, 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120, 180 |
| CCK secretion (evaluated by iAUC) | Baseline, 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120, 180 |
| Gherlin secretion (evaluated by iAUC) | Baseline, 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120, 180 |
| Changes in bile acids/FGF-19 | Baseline, 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120, 180 |
| TSH/T3/T4 | 0, 60, 120, 180 |
| Appetite measurements (VAS-score) | Baseline, 30, 60, 120, 180 |
| D009750 |
| Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |
| D003840 | Deoxycholic Acid |
| D002793 | Cholic Acids |
| D001647 | Bile Acids and Salts |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D002757 | Cholanes |