Effects of Bile Acids on GLP-1 Secretion After Roux-en-Y Gastric Bypass

Effects of Ursodeoxycholic Acid and Chenodeoxycholic Acid on GLP-1 Secretion After Roux-en-Y Gastric Bypass

The purpose of this study is to examine the effects of bile acids on GLP-1 secretion after Roux-en-Y gastric bypass.

Inclusion Criteria:

• Uncomplicated RYGB performed minimum 3 months prior to the study.
• Fasting plasma glucose < 7.0mM, HbA1c < 48mmol/mol 3 months after RYGB.

Exclusion Criteria:

• Fasting plasma glucose > 7.0mM, HbA1c > 48mmol/mol 3 months after RYGB.
• Dysregulated hypothyroidism, use of antithyroid treatment.
• Late diabetic complications as retinopathy, renal insufficiency, neuropathy or previous pancreatitis.
• Complications to RYGB: Documented reactive hypoglycaemia, severe dumping (vomiting, diarrhea, severe abdominal pain after food intake).