Primary hypothesis:

The objective compliance ( # of hours per night of APAP therapy) is higher in patients who get the APAP treatment initiation at home due to the fact that they get better support by telemetric control and the possibility of prompt interventions.

Secondary hypothesis:

Based on the higher support at the home APAP initiation the following parameters will be better in comparison to the standard supply in laboratory:

Objective measures:

• mask leakage
• pressure
• Apnea-Hypopnea-Index (AHI)

Subjective measures:

• quality of life
• sleepiness

Inclusion Criteria:

• written informed consent from patients after verbally and written informing
• Age between 18 and 80 Years
• obstructive sleep apnea syndrome (OSAS) with an AHI > 15/h and without previous therapy

Exclusion Criteria:

• Intolerance to wear the PAP therapy mask
• sleep breathing disorders (SBD) with central apneas > 20% and other sleep disorders
• disabilities who prevents the wear of a therapy mask
• initiated PAP therapy
• pre-treatment of OSAS incl. UPPP (uvulo palato pharyngo plasty)
• modified Mallampati Score T3 and T4
• participation on clinical studies 4 weeks before start of the study
• known or acute psychiatric/neurological or psychological disorders, who impairs the compliance to take part of the study.
• chronical or new clinically significant pneumological or cardiovascular disease (exception: effectively therapies of hypertension, cardiac arrhythmia and coronal cardiac disease)
• acute internistic disease
• neuromuscular disease
• condition after Apoplexy
• oncological disease in recent 5 years
• drug/alcohol consumption
• consumption of von psychotropic drugs, hypnotics and other drugs who are able to influence the sleep/wake cycle