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The purpose of this study is to determine whether febuxostat and benzbromarone could protect renal function, and which one could be better.
Chronic kidney disease patients with hyperuricemia and glomerular filtration rate (GFR) 20-50 ml/min were treated by febuxostat or benzbromarone. Follow up the changes of serum uric acid, serum creatinine and GFR levels. Compare the effects on renal function of these two drugs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Febuxostat | Experimental | take orally, 40mg per day, for 1 year |
|
| Benzbromarone | Experimental | take orally, 50mg per day, for 1 year |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Febuxostat | Drug | It acts as an inhibitor of xanthine oxidase, thus lowering urate concentrations in the body |
|
| Measure | Description | Time Frame |
|---|---|---|
| Renal function | Blood test for serum uric acid and creatinine, according to equation to estimate glomerular filtration rate | up to 12th months |
| Measure | Description | Time Frame |
|---|---|---|
| urine protein | urine test for microprotein markers and 24-hour urine protein quantitation | 3rd months, 6th months, 9th months, 12th months |
| adverse drug reaction | record all the adverse drug reactions |
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Inclusion Criteria:
Chronic kidney disease patients with glomerular filtration rate (GFR,20-50ml/min) who match one of the following criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ling Wang, MD, PhD | Department of Nephrology & Rheumatology, Shanghai Tenth People's Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Nephrology & Rheumatology, Shanghai Tenth People's Hospital | Shanghai | Shanghai Municipality | 200072 | China |
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| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| D033461 | Hyperuricemia |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D000069465 | Febuxostat |
| D001553 | Benzbromarone |
| ID | Term |
|---|---|
| D013844 | Thiazoles |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D001393 | Azoles |
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| Benzbromarone | Drug | It is structurally related to the antiarrhythmic amiodarone, and it is a uricosuric agent and non-competitive inhibitor of xanthine oxidase |
|
|
| 1st month, 2nd months, 3rd months, 6th months, 9th months, 12th months |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006573 |
| Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D001572 | Benzofurans |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |