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Persistent pain after breast cancer surgery (PPBCS) affects 25-60% of breast cancer survivors and nerve damage has been implicated as the cause of this neuropathic pain condition. Local anaesthetic blockade of tenderpoints and the intercostobrachial nerve (ICBN) could provide clues to pathophysiological mechanisms as well as aiding diagnosis and treatment of PPBCS but has never been attempted. The aims of this study is to examine clinical effect of ultrasound guided blockades of the ICBN and tenderpoints of pain.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ICBN, active | Experimental | Ultrasound guided injection of bupivacain, 10mL, 0.5% in proximity of the ICBN |
|
| ICBN, placebo | Placebo Comparator | Ultrasound guided injection of NaCl, 10mL in proximity of the ICBN |
|
| Tenderpoint, active | Experimental | Ultrasound guided injection of bupivacain, 20mL, 0.25% in the tenderpoint |
|
| Tenderpoint, placebo | Placebo Comparator | Ultrasound guided injection of NaCl, 20mL in the tenderpoint |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bupivacaine | Drug |
| ||
| NaCl |
| Measure | Description | Time Frame |
|---|---|---|
| Summed pain intensity | The summed pain intensity (of pain at rest (0-10), pain during movement (0-10) and pressure pain (at 100kPa in point of maximum pain) (0-10)) 0-30 | At least 1 year after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Pain at rest, pain during movement and pressure pain | Pain intensity of pain at rest (0-10), pain during movement (0-10) and pressure pain (at 100kPa in point of maximum pain) (0-10) | At least 1 year after surgery |
| Pain related reduction of physical function |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nelun Wijayasinghe, MD | Contact | +4535454496 | nelun.wijayasinghe@regionh.dk |
| Name | Affiliation | Role |
|---|---|---|
| Nelun Wijayasinghe, MD | Rigshospitalet, University of Copenhagen | Principal Investigator |
| Kenneth G Andersen, MD, PhD | Rigshospitalet, University of Copenhagen | Study Chair |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24918332 | Background | Wijayasinghe N, Andersen KG, Kehlet H. Neural blockade for persistent pain after breast cancer surgery. Reg Anesth Pain Med. 2014 Jul-Aug;39(4):272-8. doi: 10.1097/AAP.0000000000000101. |
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| ID | Term |
|---|---|
| D010146 | Pain |
| D009437 | Neuralgia |
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010523 | Peripheral Nervous System Diseases |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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|
Reduction of physical function |
| At least 1 year after surgery |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D000588 |
| Amines |