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A prospective Observational study including 50 living donor liver transplant recipients to monitor the graft functions through thromboelastometry
This is a prospective observational study Includes 50 living donor liver transplant recipients performed in gastroenterology surgical center - Mansoura University liver transplantation program.
Study period: from June 2014 to May 2015 The early post-operative graft functions will be correlated with concomitant monitored thromboelastometric (TEM) parameters derived from a ROTEM Delt device
TEM Samples will be collected at the following times:
Pre-transplant 10 minutes post portal declamping at ICU admission Morning of Days from 1 to 7 Laboratory data relevant to graft functional status will be collected at the same times.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LDLT Recipients | Patients subjected to living donor liver transplantation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| living donor liver transplantation | Procedure | living donor liver transplantation |
|
| Measure | Description | Time Frame |
|---|---|---|
| r (correlation coefficient) between clot firmness time at 20 minutes, clotting time and INR | Both blood sample for INR and other lab test and the sample for TEG will be simultaneously drawn from the arterial line for reading of days 0,1 and 2 then from the CVP for the rest of the study readings | 20 minutes after starting the TEG test |
| Measure | Description | Time Frame |
|---|---|---|
| r (correlation coefficient) between clotting time , clot firmness time at 20 minutes and serum bilirubin | 20 minutes after the start of the TEG test | |
| r (correlation coefficient) between clotting time , clot firmness time at 20 minutes and serum SGPT | 20 minutes after the start of the TEG test |
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Inclusion Criteria:
Exclusion Criteria:
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Living donor liver transplant recipients operated upon in mansoura university liver transplantion project
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| Name | Affiliation | Role |
|---|---|---|
| amr M Yassen, MD | MAnsoura Faculty of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gastroenerology Surgical Center - Liver transplantation program | Al Mansurah | Dakahlia Governorate | 35516 | Egypt |
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