Sponsor decision due to the low recruitment rate

The purpose of this study is to evaluate of gender differences on the psychosocial and economic impact in patients with advanced non-small cell lung cancer.

Multi-centre, prospective follow-up post-authorisation study of two patient cohorts with metastatic NSCLC (men and women). It will be stratified based on biological sex, age and smoking to guarantee homogeneity between the cohorts. The clinical procedures for assessing the tumour and the treatment response will be performed according to the site's standard practice.

Inclusion Criteria:

• Patients diagnosed with stage IV NSCLC who are going to commence first line treatment
• Patients over the age of 18
• ECOG 0-3
• Patients who have granted their informed consent, preferably in writing, but otherwise, verbal with witnesses who are independent of the research team
• Life expectancy of over three months
• Speak fluent Spanish, in order to be able to complete the study questionnaires
• Patients able to read and write with no problems

Exclusion Criteria:

• Previous systemic treatment for metastatic NSCLC. The administration of neoadjuvant or adjuvant radiotherapy and/or chemotherapy is permitted provided it was completed major or equal 6 months prior
• Dementia or a significantly altered mental state that could affect comprehension or the ability to grant informed consent

Approximately 1250 patients over 18 years of age (approximately 50% men/women), with metastatic NSCLC, who are going to commence first-line treatment and who have a life expectancy of over three months will be included. They will be distributed into two cohorts (men and women) at 50% and will be distributed by age group and smoking status to facilitate the homogeneity between the two cohorts.