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| ID | Type | Description | Link |
|---|---|---|---|
| 2014-A01302-45 | Registry Identifier | ANSM | |
| RCAPHM14_0343 | Other Identifier | APHM |
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Identifying hypercortisolism patients at risk for cardio-vascular events despite biological cure, and determine which patients should be particularly followed. Hypercortisolic patients represent an ideal in vivo model to determine the interactions between glucocorticoids and ectopic fat development.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients with active hypercortisolism | Active Comparator |
| |
| Patients in remission of their hypercortisolism after surgery | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood samples for measuring adiponectin, leptin and omentin plasma | Biological |
|
| Measure | Description | Time Frame |
|---|---|---|
| measuring the volume of epicardial adipose tissue, as measured by MRI to 3 Tesla. | 36 months | |
| Assess insulin resistance by the blood sugar and insulin levels | 36 months | |
| Assess cardiovascular risk by a blood complete lipid profile | 36 months |
| Measure | Description | Time Frame |
|---|---|---|
| Assess insulin resistance by the blood leptin, adiponectin and omentin plasma level | 36 months | |
| Assess cardiovascular risk by the blood leptin, adiponectin and omentin plasma level | 36 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Urielle DESALBRES, Director | Asistance Publique Hôpitaux Marseille | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Assistance Publique Hôpitaux Marseille | Marseille | 13354 | France |
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| ID | Term |
|---|---|
| D003480 | Cushing Syndrome |
| ID | Term |
|---|---|
| D000308 | Adrenocortical Hyperfunction |
| D000307 | Adrenal Gland Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D020738 | Leptin |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| MRI at 3 Tesla | Device | Evaluation by MRI at 3 Tesla of the amount of ectopic fat heart, liver and pancréas and bone marrow. |
|
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D054392 | Adipokines |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D036341 | Intercellular Signaling Peptides and Proteins |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D011506 | Proteins |
| D001685 | Biological Factors |