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Chronic fatigue syndrome (CFS) is characterized by unexplained, disabling and long lasting fatigue, as well as pain, impaired memory, sleep difficulties and other symptoms. Epstein-Barr virus (EBV) infection might precipitate CFS. In this study, 200 adolescents undergoing acute EBV infection will be followed prospectively, and also compared with a group of healthy controls. The aim is twofold:
Possible risk factors for chronic fatigue 6 months after EBV-infection includes:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute EBV infection | |||
| Healthy controls |
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| Measure | Description | Time Frame |
|---|---|---|
| Fatigue | Chalder fatigue questionnaire, total score | 6 monhts |
| Steps per day | Mean number of steps/day across 7 consecutive days, measured by accelerometer (ActivePal) | 6 monhts |
| Measure | Description | Time Frame |
|---|---|---|
| Pain threshold | Assessed by pressure algometry | 6 monhts |
| Autonomic cardiovascular control | Assessed by noninvasive, continuous recordings of heart rate, blood pressures and stroke volume during supine rest. |
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Inclusion Criteria:
Exclusion Criteria:
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Microbiological laboratories serving the population of Oslo and neighbour conties.
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| Name | Affiliation | Role |
|---|---|---|
| Vegard B Wyller | University Hospital, Akershus | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dept. of Pediatrics, Akershus University Hospital | Lørenskog | Akershus | N-1478 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34987499 | Derived | Fevang B, Wyller VBB, Mollnes TE, Pedersen M, Asprusten TT, Michelsen A, Ueland T, Otterdal K. Lasting Immunological Imprint of Primary Epstein-Barr Virus Infection With Associations to Chronic Low-Grade Inflammation and Fatigue. Front Immunol. 2021 Dec 20;12:715102. doi: 10.3389/fimmu.2021.715102. eCollection 2021. | |
| 30261303 | Derived |
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| ID | Term |
|---|---|
| D015673 | Fatigue Syndrome, Chronic |
| D020031 | Epstein-Barr Virus Infections |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D004679 | Encephalomyelitis |
| D000090862 | Neuroinflammatory Diseases |
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| 6 monhts |
| Cognitive function | Assessed by the instruments WISC-IV, D-KEFS, HVLT-R and WASI. | 6 monhts |
| Neuroendocrine markers | In particular blood and urine measurements of catecholamines and the HPA axis | 6 monhts |
| Immune markers | In particular blood measurements of cytokines | 6 monhts |
| Bodily symptoms | Assessed by different questionnaires | 6 monhts |
| Quality of life | Assessed by the PedsQL inventory | 6 monhts |
| Functional disability | Assessed by the FDI inventory | 6 monhts |
| Pedersen M, Asprusten TT, Godang K, Leegaard TM, Osnes LT, Skovlund E, Tjade T, Oie MG, Wyller VBB. Predictors of chronic fatigue in adolescents six months after acute Epstein-Barr virus infection: A prospective cohort study. Brain Behav Immun. 2019 Jan;75:94-100. doi: 10.1016/j.bbi.2018.09.023. Epub 2018 Sep 25. |
| D009422 | Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006566 | Herpesviridae Infections |
| D004266 | DNA Virus Infections |
| D014777 | Virus Diseases |
| D007239 | Infections |
| D014412 | Tumor Virus Infections |