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| Name | Class |
|---|---|
| Ministry for Health and Solidarity, France | OTHER_GOV |
| National Cancer Institute, France | OTHER_GOV |
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PEComa is rare tumor affecting particularly patients with Tuberous Sclerosis. Biological similarities were seen between PEComa and infantile hemangioma. Propranolol is highly efficient to treat infantile hemangioma and we believe that this drug can also be useful for the treatment of PEComa.
Purpose : to understand the mechanism of action of propranolol in PEComas and related pediatric vascular lesions and to select possible novel targets of betablockers in vascular tumors related to PEComas by using YAP oncogene activation as a molecular marker
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients | Patients who will have biopsy or surgery for Perivascular epithelioid cell tumor (PEComa) or vascular pediatric tumor (Rapidly Involuting Congenital Hemangioma (RICH), Non Involuting Congenital Hemangioma (NICH), hemangioma or pyogenic granuloma) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biopsy | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| YAP cellular expression by immunohistochemistry study on collected tissues | At inclusion (day 0)] |
| Measure | Description | Time Frame |
|---|---|---|
| Beta adrenergic receptors expression by immunohistochemistry study on collected tissues | At inclusion (day 0)] | |
| Study of Hippo/YAP pathway expression by western-blot, and correlation with propranolol efficacy | At inclusion (day 0)] |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who will have biopsy or surgery for PEComa or vascular pediatric tumor (RICH, NICH, hemangioma or pyogenic granuloma)
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Bordeaux | Bordeaux | 33000 | France |
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| ID | Term |
|---|---|
| D054973 | Perivascular Epithelioid Cell Neoplasms |
| D006391 | Hemangioma |
| ID | Term |
|---|---|
| D018204 | Neoplasms, Connective and Soft Tissue |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009383 | Neoplasms, Vascular Tissue |
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| ID | Term |
|---|---|
| D001706 | Biopsy |
| ID | Term |
|---|---|
| D003581 | Cytodiagnosis |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
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| Study of MAP/kinases pathway expression by western-blot, and correlation with propranolol efficacy | At inclusion (day 0)] |
| Study of PKA/AMPc pathway expression by western-blot, and correlation with propranolol efficacy | At inclusion (day 0)] |
| D003933 | Diagnosis |
| D013048 | Specimen Handling |
| D003949 | Diagnostic Techniques, Surgical |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |