Not provided
Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 81403441 | Other Grant/Funding Number | National Natural Science Foundation of China |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Due to the change of life style, the incidence of oral cavity mucous membrane disease increased.In this studyļ¼been done a large number of pre-clinical practice and some experimental studiesļ¼ based on the application of metabolomics technology to ultra-high liquid-mass spectrometry metabolomics analyzer as the core meansļ¼ The metabolism of pattern recognition and combination of modern analytical techniques to measure blood and urine of patients with OLP-specific clearance of endogenous metabolitesļ¼and after the intervention of moss drink endogenous metabolites in the body as a whole group of. At the same timeļ¼ the use of flow cytometry,ļ¼ELISAļ¼ immunohistochemistry and other modern technology, research OLP patients using clean moss drink before and after treatment of local lesions and peripheral blood CD4 +ļ¼CD8 + lymphocytesļ¼Th1 cytokines (IFN-Ī³ļ¼ TNF-Ī±)ļ¼ Th2 cytokines (IL-4ļ¼10) the dynamic changes. From metabolomicsļ¼ cellular immunologyļ¼ inflammation mechanism perspective of local OLP lesionsļ¼ peripheral blood and changes in endogenous metabolites in the process,ļ¼in-depth study of traditional Chinese medicine to drink clean moss multi-component multi-target treatment of this disease mechanismļ¼ is widely used in traditional Chinese medicine treatment of OLP provide a theoretical basis for the promotion of Chinese medicine Qingxian Yin in the oral mucosal disease in the applicationļ¼ effectively solve clinical practice problems.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervene | Active Comparator | For Qingxuan Decoction there are a bag of Chinese honeylocust spineļ¼Glehnia littoralis and Smilax china L,and two bags of Silktree albizia bark, Kadsura interior,Cortex dictamni, Lilium brownii var, Silkworm larva,Forsythia suspensa and Rhizoma polygonati preparata, and three bags of viridulumArisaema erubescens and Poria cocos Wolf. All drugs are made by Jiangyin Tianjiang company in China. Qingxuan Decoction is given two times after breakfast and dinner in 56 days. |
|
| Blank | No Intervention | There is no intervention for people in the blank group. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Qingxuan Decoction | Drug | In Qingxuan Decoction, there are a bag of Chinese honeylocust spineļ¼Glehnia littoralis and Smilax china L,and two bags of Silktree albizia bark, Kadsura interior,Cortex dictamni, Lilium brownii var, Silkworm larva,Forsythia suspensa and Rhizoma polygonati preparata, and three bags of viridulumArisaema erubescens and Poria cocos Wolf. All drugs are made by Jiangyin Tianjiang company in China. |
| Measure | Description | Time Frame |
|---|---|---|
| visualanalogue scale | every week of eight weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Cytokines | IFN-Ī³, TNF-Ī±, IL-4 and IL-10 of the blood cells of CD4+/CD8+ and Th1/Th2 will be tested by flow cytometry or ELISA. | every week of eight weeks |
| Cytokines | IFN-Ī³, TNF-Ī±, IL-4 and IL-10 of the lesion tissue cells of CD4+/CD8+ and Th1/Th2 will be tested by immunohistochemistry |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yang Xu Yan, Doctor | Contact | +86 0451-82193038 | 444125750@qq.com |
| Name | Affiliation | Role |
|---|---|---|
| Yang Xu Yan, Doctor | University of Chinese Medicine Department of Stomatology, Heilongjiang University of Chinese Medicine. | Principal Investigator |
Not provided
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17822813 | Result | Scully C, Carrozzo M. Oral mucosal disease: Lichen planus. Br J Oral Maxillofac Surg. 2008 Jan;46(1):15-21. doi: 10.1016/j.bjoms.2007.07.199. Epub 2007 Sep 5. | |
| 3144585 | Result | Holmstrup P, Thorn JJ, Rindum J, Pindborg JJ. Malignant development of lichen planus-affected oral mucosa. J Oral Pathol. 1988 May;17(5):219-25. doi: 10.1111/j.1600-0714.1988.tb01528.x. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D017676 | Lichen Planus, Oral |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D008010 | Lichen Planus |
| D017512 | Lichenoid Eruptions |
Not provided
Not provided
| ID | Term |
|---|---|
| C000723273 | Jiawei qingxuan jiangya decoction |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| rvery week of eight weeks |
| Biomarker | Metabolites profiles of individual in the intervention group will be analysed by PCAćOPLS-DA or UPLC-MS. | every week of eight weeks |
| 14662419 | Result | Gandolfo S, Richiardi L, Carrozzo M, Broccoletti R, Carbone M, Pagano M, Vestita C, Rosso S, Merletti F. Risk of oral squamous cell carcinoma in 402 patients with oral lichen planus: a follow-up study in an Italian population. Oral Oncol. 2004 Jan;40(1):77-83. doi: 10.1016/s1368-8375(03)00139-8. |
| 16128740 | Result | Chaiyarit P, Ma N, Hiraku Y, Pinlaor S, Yongvanit P, Jintakanon D, Murata M, Oikawa S, Kawanishi S. Nitrative and oxidative DNA damage in oral lichen planus in relation to human oral carcinogenesis. Cancer Sci. 2005 Sep;96(9):553-9. doi: 10.1111/j.1349-7006.2005.00096.x. |
| 15972624 | Result | Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. 1986. J Immunol. 2005 Jul 1;175(1):5-14. No abstract available. |
| 23675060 | Result | Lee YC. Synergistic effect of various regulatory factors in TH1/TH2 balance; immunotherapeutic approaches in asthma. Int J Biomed Sci. 2008 Mar;4(1):8-13. |
| 8600944 | Result | Krouwels FH, van der Heijden JF, Lutter R, van Neerven RJ, Jansen HM, Out TA. Glucocorticosteroids affect functions of airway- and blood-derived human T-cell clones, favoring the Th1 profile through two mechanisms. Am J Respir Cell Mol Biol. 1996 Apr;14(4):388-97. doi: 10.1165/ajrcmb.14.4.8600944. |
| 11331037 | Result | Agarwal SK, Marshall GD Jr. Dexamethasone promotes type 2 cytokine production primarily through inhibition of type 1 cytokines. J Interferon Cytokine Res. 2001 Mar;21(3):147-55. doi: 10.1089/107999001750133159. |
| 12969224 | Result | van der Meij EH, van der Waal I. Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications. J Oral Pathol Med. 2003 Oct;32(9):507-12. doi: 10.1034/j.1600-0714.2003.00125.x. |
| 16386358 | Result | Mendoza L. A network model for the control of the differentiation process in Th cells. Biosystems. 2006 May;84(2):101-14. doi: 10.1016/j.biosystems.2005.10.004. Epub 2005 Dec 28. |
| D017444 |
| Skin Diseases, Papulosquamous |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |