Airway Response to Repeat Allergen Challenge and the Effect of Ibuprofen in Mild Atopic Asthma

Assessment of Repeated Allergen Challenge and the Effects of Ibuprofen on the Inflammatory Process

The study will assess airway responses in mild atopic asthmatics undergoing repeat allergen challenge testing and will investigate whether ibuprofen changes the response.

Inclusion Criteria:

• diagnosis of mild asthma, currently well controlled requiring only a bronchodilator (e.g. salbutamol) as needed and infrequently
• has allergies that trigger asthma
• responds to methacholine challenge at 16mg/ml or less
• has FEV1 > 69.5% predicted

Exclusion Criteria:

• respiratory illness within 4 weeks
• other medical condition assessed by the principal investigator that would put the participant at risk or influence the integrity of the data
• pregnant or lactating females
• hypersensitivity to ibuprofen