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| Name | Class |
|---|---|
| Hospital Clinic of Barcelona | OTHER |
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The main aim is to analyze whether the routine use of chest physiotherapy in non cystic fibrosis bronchiectasis (NCFB) improves the cough severity and the quality of life in this population. In addition, the secondary end-points include incidences of exacerbations, changes in lung function, exercise capacity, airways inflammation, sputum analysis and eventual adverse events.
The present project will be a single-blind , randomized, controlled trial of 12-month daily performing chest physiotherapy compared with usual care, followed by a 3-month intervention-free in non-cystic fibrosis bronchiectasis.
Intervention group will perform daily autonomous airway clearance techniques (positive expiratory pressure technique through Acapella device and autogenic drainage technique). Patients will receive professional sessions once a month.
Control group will receive their usual care and educational sessions about their disease. Physiotherapist will call them once a month.
During the study period the patients' pharmacological treatment remained unchanged
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Usual care | No Intervention | Subjects will receive the usual medical care in accordance with Spanish non cystic fibrosis bronchiectasis guidelines. In addition they will receive educational sessions about their disease and their pharmacology treatment. | |
| Chest physiotherapy plus usual care | Experimental | Subjects will introduce chest physiotherapy as part of their daily treatment |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Chest physiotherapy plus usual care | Other | Subjects will perform daily chest physiotherapy during at least 30 minutes. Patients will perform a slow expiratory airway clearance technique combined with positive expiratory pressure device (Acapella device, Murray et al.) Each patient will receive 12 supervised professional sessions (once a month). |
| Measure | Description | Time Frame |
|---|---|---|
| Cough severity (Auto-administered questionnaire: Leicester Cough Questionnaire) | Auto-administered questionnaire: Leicester Cough Questionnaire | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Quality of life (Quality of life-Bronchiectasis questionnaire) | Auto-administered questionaire: Quality of Life- Bronchiectasis | 1 year |
| Exacerbation frequency | Number of exacerbation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Beatriz Herrero, Msc | Universidad San Jorge | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidad San Jorge | Zaragoza | 50830 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19541717 | Background | Murray MP, Pentland JL, Hill AT. A randomised crossover trial of chest physiotherapy in non-cystic fibrosis bronchiectasis. Eur Respir J. 2009 Nov;34(5):1086-92. doi: 10.1183/09031936.00055509. Epub 2009 Jun 18. |
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| ID | Term |
|---|---|
| D001987 | Bronchiectasis |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
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| 1 year |
| Exercise capacity (Incremental field test: shuttle test) | Incremental field test: shuttle test | 1 year |
| Lung function | Simple spirometry: Forced expiratory volume at 1 second, Forced vital capacity, Forced expiratory flow 25-75 | 1 year |
| Airway inflammation as assessed by spontaneous sputum analysis | Inflammatory sputum markers: Myeloperoxidase (MPO) and Cytokines (IL-8) | 1 year |