Comparison of Emergence and Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia

Comparison of Emergence and Recovery Time, and Evaluation of Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia in Lung Surgery- A Pilot Study

Which is more adequate general anesthetic agent, desflurane or propofol, for emergence and recovery time, and perioperative oxygenation in lung resection surgery?

The investigators plan to investigate the effects of desflurane on oxygenation (prevention of HPV) of OLV compare with propofol which is used in general anesthesia for lung resection.

Transesophageal echocardiography (TEE) wiill be used to measure pulmonary blood flow during surgery visible and successively. To confirm the effect of HPV by measuring the change in pulmonary blood flow. The correlation between the blood oxygen concentration and attenuation of blood flow will be investigated.

Inclusion Criteria:

• Patients agree to participate in the study
• Patients undergoing lung cancer surgery requiring one-lung ventilation.
• American Society of Anesthesiologists Physical Status Class 1 or 2

Exclusion Criteria:

• Patients with any of the following will be excluded from lung cancer patients.
• New York Heart Association Classification more than 2
• Respiratory dysfunction Vital Capacity or percent predicted Forced expiratory volume in one second is less than 50 %
• Pulmonary hypertension with mean pulmonary arterial pressure more than 30 mmHg
• Coagulation dysfunction
• The administration of steroids and immunosuppressive agents within 3 months prior to surgery
• Infection with active inflammation
• Pneumonectomy patients
• Cases of epidural anesthesia is contraindicated