Isolated Anti-HBc Serological Profile in HIV Infected Patients: Immunological, Virological Characteristics and Response to Hepatitis B Vaccination

Study of Immunological, Virological, Serological Characteristics of HIV+ Patients Harboring Isolated Anti-HBc Profile and Response to Hepatitis B Vaccination

The aim of study is to describe the clinical, immunological, serological, virological and therapeutic characteristics of HIV+ patients harboring isolated anti-HBc profile and to assess the response to vaccination in these patients.

Inclusion Criteria:

• HIV+ adults patients
• negative HBsAg
• negative a-HBs Ab
• positive HBc Ab
• without HBV - vaccination
• CD4 cell above 200 /mm3
• HIV viral load below 50 copies/mL

Exclusion Criteria:

• positive HBs antigenemia in the past
• transaminitis above fivefold upper normal limit
• PT<50% or Platelet <50 000/mm3
• ongoing opportunistic infection
• ongoing or recent systemic corticoid or immunomodulatory therapy, splenectomy, pregnancy, contra-indication to intramuscular injection, familial history of neurological disease.