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| ID | Type | Description | Link |
|---|---|---|---|
| 2010-A00511-38 | Other Identifier | ANSM |
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The aim of study is to describe the clinical, immunological, serological, virological and therapeutic characteristics of HIV+ patients harboring isolated anti-HBc profile and to assess the response to vaccination in these patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| vaccination | Anti-HBV vaccine injection |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood sampling | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of immunological, virological and serological characteristics associated to "anti-HBc isolated" profile | at Day 0, inclusion visite | |
| Average titers of anti-HBs Ab | at 4 weeks, 28 weeks and 18 months after the first vaccination HBV | |
| Analysis of B-cell phenotype and maturation | at baseline and at week 28 |
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients with HBsAb titers as protective titer>10 IU/L | at 4 weeks,28 weeks and 18 month after the first dose HBV vaccin | |
| Detection of IgG+ memory B cells specific for HBcAg or HBs Ag | at baseline and 28 weeks after the first dose HBV vaccin |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with HIV infection and presenting with "isolated anti-HBc" profile. HBV vaccination is recommended fot these patients.
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| Name | Affiliation | Role |
|---|---|---|
| Lionel Piroth | CHU DIJON | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu Dijon | Dijon | France |
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| - Detection of HBV preS2 and S-specific T cells | at day 0 and week 28 |
| ID | Term |
|---|---|
| D015658 | HIV Infections |
| D006509 | Hepatitis B |
| ID | Term |
|---|---|
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D015229 | Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |
| D018347 | Hepadnaviridae Infections |
| D004266 | DNA Virus Infections |
| D006525 | Hepatitis, Viral, Human |
| D006505 | Hepatitis |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
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