Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim of this study is first to assess if desflurane is superior in order to achieve a faster emergence from anesthesia.
The aim of this study is first to assess if desflurane is superior in order to achieve a faster emergence from anesthesia (stating the date of birth) and second if desflurane is non-inferior in the occurrence of airway complications compared to sevoflurane or total intravenous anesthesia with propofol in the setting of laryngeal mask airway.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| desflurane | Experimental | Suprane® Dose: 0.8 MAC / 4-5 vol. % Mode of administration: inhalation with laryngeal mask One application |
|
| sevoflurane | Active Comparator | Sevoflurane: Dose: 0.8 MAC / 1.2-1.4 vol.% Mode of administration: inhalation with laryngeal mask One application |
|
| propofol | Active Comparator | Propofol Dose: 5-7 mg kg-1 h-1 to maintain a BIS index value between 40 and 60 Mode of administration: intravenous One application |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Desflurane | Drug | inhalation with laryngeal mask to maintain anaesthesia |
|
| Measure | Description | Time Frame |
|---|---|---|
| time of emergence from anesthesia | time of emergence from anesthesia defined as time between cessation of anesthesia until patient is able to state his/her date of birth on command | up to 15 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Airway reactions (Incidence of intraoperative coughs, laryngospasm) | Incidence of intraoperative coughs (induction/maintenance) - non-inferiority design Incidence of intraoperative laryngospasm (induction/maintenance) Incidence of cough at emergence Incidence of laryngospasms at emergence | up to 2 hours |
| Emergence times |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Mark Coburn, Prof. | University Hospital, Aachen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| RWTH Aachen University; Department of Anesthesia | Aachen | D-52074 | Germany | |||
| Martha-Maria Hospital Halle Dölau gGmbH, Department of Anesthesia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29916859 | Derived | Kowark A, Rossaint R, Puhringer F, Keszei AP, Fritz H, Froba G, Rex C, Haas H, Otto V, Coburn M; Study Collaborators. Emergence times and airway reactions during general anaesthesia with remifentanil and a laryngeal mask airway: A multicentre randomised controlled trial. Eur J Anaesthesiol. 2018 Aug;35(8):588-597. doi: 10.1097/EJA.0000000000000852. | |
| 26210907 |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D000077335 | Desflurane |
| D000077149 | Sevoflurane |
| D015742 | Propofol |
| ID | Term |
|---|---|
| D005019 | Ethyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D008738 | Methyl Ethers |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Sevoflurane | Drug | inhalation with laryngeal mask to maintain anaesthesia |
|
|
| propofol | Drug | intravenous injection to maintain anaesthesia |
|
|
Time to remove laryngeal mask Time to open eyes on command Time to respond on command (press hand) Time to state the name on command Recovery Index (RI = 1 + Aldrete5min/[(2xextubation time) + 1 x opening eyes time)] |
| up to 15 minutes |
| Halle |
| 06120 |
| Germany |
| Kreiskliniken Reutlingen, Department of Anesthesia | Reutlingen | 73764 | Germany |
| University Hospital Ulm, Department of Anesthesia | Ulm | 89075 | Germany |
| Stevanovic A, Rossaint R, Keszei AP, Fritz H, Froba G, Puhringer F, Coburn M. Emergence times and airway reactions in general laryngeal mask airway anesthesia: study protocol for a randomized controlled trial. Trials. 2015 Jul 26;16:316. doi: 10.1186/s13063-015-0855-2. |
| D006845 |
| Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |