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Mask ventilation during induction of anesthesia can be improved by administration of neuromuscular blocking agents (NMBAs). NMBAs are usually administered after testing mask ventilation; however, muscle relaxants may improve mask ventilation and they do not alter mask ventilation. Thus, growing evidence suggests to administer muscle relaxants before testing mask ventilation. We will study different dosages of rocuronium; we assume that higher dosages of rocuronium will improve mask ventilation compared with lower dosages.
Mask ventilation during induction of anesthesia can be improved by administration of neuromuscular blocking agents (NMBAs). NMBAs are usually administered after testing mask ventilation; however, muscle relaxants may improve mask ventilation and they do not alter mask ventilation. Thus, growing evidence suggests to administer muscle relaxants before testing mask ventilation.We will administer rocuronium 0.3 mg/kg, 0.6 mg/kg, 0.9 mg/kg and saline (placebo group) before starting with mask ventilation. We will grade mask ventilation based on various scores before and after rocuronium application. Afterwards patient's tracheas will be intubated. We assess risk factors for difficult mask ventilation.
We hypothesize that rocuronium 0.9 mg/kg will be superior to rocuronium 0.3 mg/kg and saline.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rocuronium 0.3 mg/kg | Active Comparator | Patients receive rocuronium 0.3 mg/kg |
|
| Rocuronium 0.6 mg/kg | Active Comparator | Patients receive rocuronium 0.6 mg/kg |
|
| Rocuronium 0.9 mg/kg | Active Comparator | Patients receive rocuronium 0.9 mg/kg |
|
| Placebo | Placebo Comparator | Patients receive saline |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rocuronium 0.3 mg/kg | Drug | Patients receive rocuronium 0.3 mg/kg |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of improved mask ventilation after rocuronium administration | Graded with various scores | Two minutes after rocuronium administration |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Thomas Mencke, Prof. | University of Rostock | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesia and Intensive Care Medicine, University of Rostock | Rostock | Mecklenburg-Vorpommern | 18057 | Germany |
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| ID | Term |
|---|---|
| D009123 | Muscle Hypotonia |
| ID | Term |
|---|---|
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D000077123 | Rocuronium |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D000732 | Androstanols |
| D000731 | Androstanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
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| Rocuronium 0.6 mg/kg | Drug | Patients receive rocuronium 0.6 mg/kg |
|
|
| Rocuronium 0.9 mg/kg | Drug | Patients receive rocuronium 0.9 mg/kg |
|
|
| Placebo | Drug | Patients receive saline |
|
|
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011083 |
| Polycyclic Compounds |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |