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| Name | Class |
|---|---|
| The Scientific and Technological Research Council of Turkey | OTHER |
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The most effective treatment of hematologic malignancies and some benign hematological diseases is allogeneic stem cell transplantation therapy. Pulmonary complications can occur after allogeneic stem cell transplantation. And these complications effect mortality and morbidity in these patients. In this study we want to investigate the use of exhaled breath condensate (EBC) collection which is a simple and completely noninvasive method. By this way we hope to detect pulmonary complications early. EBC, has been implicated in the pathophysiology of inflammatory airway diseases such as cystic fibrosis, asthma, chronic obstructive pulmonary disease (COPD) and bronchiectasis. EBC, has not been investigated before in patients who underwent stem cell transplantation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| EBC level | Exhaled breath condensate level of allogeneic stem cell transplantation patients |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exhaled breath condensate | Other | Breath condensate samples will be collected with a commercially available condenser (EcoScreen®, Erich Jaeger, Germany). Subjects will breathe through a mouthpiece and a two-way non-rebreathing value in which inspiratory and expiratory air were separated, and saliva was trapped. They will be asked to breathe at a normal frequency and tidal volume for 15 minutes while wearing nose clips, allowing collection of 1.5-2.5 mL of condensate. After collecting this, pH will be measured and the waste collection will be stored at -80 degrees. Then 8 isoprostane and nitrotyrosine will be measured collectively |
| Measure | Description | Time Frame |
|---|---|---|
| The pH level of exhaled breath condansate | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| The nitrotyrosine and 8-isoprostane levels of exhaled breath condansate | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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allogeneic stem cell transplantation patients for hematologic malignancies and some benign hematological diseases
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nilgün Yilmaz Demirci, MD | Contact | 009031224143 | nilgundemirci@gazi.edu.tr |
| Name | Affiliation | Role |
|---|---|---|
| Zeki Yıldırım, professor | Gazi University Faculty of Medicine Chest Disease Department | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16135737 | Background | Horvath I, Hunt J, Barnes PJ, Alving K, Antczak A, Baraldi E, Becher G, van Beurden WJ, Corradi M, Dekhuijzen R, Dweik RA, Dwyer T, Effros R, Erzurum S, Gaston B, Gessner C, Greening A, Ho LP, Hohlfeld J, Jobsis Q, Laskowski D, Loukides S, Marlin D, Montuschi P, Olin AC, Redington AE, Reinhold P, van Rensen EL, Rubinstein I, Silkoff P, Toren K, Vass G, Vogelberg C, Wirtz H; ATS/ERS Task Force on Exhaled Breath Condensate. Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J. 2005 Sep;26(3):523-48. doi: 10.1183/09031936.05.00029705. | |
| 16686775 |
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| Background |
| Dupont LJ, Dewandeleer Y, Vanaudenaerde BM, Van Raemdonck DE, Verleden GM. The pH of exhaled breath condensate of patients with allograft rejection after lung transplantation. Am J Transplant. 2006 Jun;6(6):1486-92. doi: 10.1111/j.1600-6143.2006.01331.x. |
| 23823823 | Background | Mo XD, Xu LP, Liu DH, Zhang XH, Chen H, Chen YH, Han W, Wang Y, Wang FR, Wang JZ, Liu KY, Huang XJ. Risk factors for bronchiolitis obliterans syndrome in allogeneic hematopoietic stem cell transplantation. Chin Med J (Engl). 2013 Jul;126(13):2489-94. |