Preoperative Single Glucocorticoid Hip Fracture Hip Fracture Surgery

Preoperative Single-high Dose Glucocorticoid for Patients Undergoing Hip Fracture Surgery and the Effect on Postoperative Delirium.

The Study is a double-blinded, randomized, placebo-controlled trials. The Objective is to investigate the effect of single-high-dose glucocorticoid on surgical stress response and postoperative delirium among Elderly hip Fracture Patients undergoing surgery.

Patients with Hip Fracture are exposed for two traumas that can trigger a stress response. The first is the fall that causes the Fracture. The second is the surgery. In this study the intervention is dispensed early in the disease course - as soon as the Fracture has been diagnosed and booked for surgery.

Inclusion Criteria:

• Patients undergoing surgery for hip fracture
• Informed signed consent
• Danish speaking

Exclusion Criteria:

• Allergies towards contents of Solu-Medrol
• Insulin dependent diabetes
• Glaucoma
• In treatment for cancer disease
• Positive HIV, Hepatitis b or C status
• Lack of informed consent (eq. Severe dementia, coma, and others)
• Current treatment with systemic glucocorticoids (pr.os or intravenous) Immunoinflammatory disease (Except topical treated skin disease and respiratory disease)
• Current Immunosuppressive treatment
• Unable to participate in CAM-S measurement
• Peptic ulcera