Imaging and Understanding BOS in Lung Transplantation

Imaging and Understanding BOS in Lung Transplantation

This study is a prospective, non-randomized, longitudinal, observational study that will recruit about 5 lung transplant patients per year for 3 years.

This study is a prospective, non-randomized, longitudinal, observational study that will recruit about 5 lung transplant patients per year for 3 years. We will follow these patients at 6 months and 1 year with Hyperpolarized Helium-3 Magnetic Resonance Imaging and image guided bronchial biopsies to detect early BOS and to better understand BO disease progression. The biopsies will provide future research for rapid determination of cellular and molecular mechanisms that lead to BOS and to facilitate identification and validation of translatable pharmaceutical targets.

Inclusion Criteria:

• Lung Transplantation within the last 10 years or being assessed for possible lung transplantation.
• Male or female
• 0 to 25 years of age.

Exclusion Criteria:

• Standard MRI exclusion criteria as set forth by the CCHMC Division of Radiology
• Inability to perform 10 second breath hold for 3He MRI scan
• Bleeding disorders