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The purpose of the research study of the K23 award is to develop a blood test that can check how much alcohol a person has consumed in the past few days. We will enroll heavy social drinkers who do not have alcohol-related problems but used to drinking 5 or more beers on a single occasion. Both men and women between ages 21 and 65 years can join the study. All participants must be of European decent.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| placebo alcohol | Placebo Comparator | <0.05% alcohol |
|
| alcohol middle dose | Active Comparator | alcohol dose=0.45g/kg for women and 0.5g/kg for men |
|
| alcohol high dose | Active Comparator | alcohol dose=0.90g/kg for women and 1.0g/kg for men |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Alcohol administration; Placebo administration | Other | consumption of 3 alcohol doses (2 regular and one placebo) each within 2h on separate days |
|
| Measure | Description | Time Frame |
|---|---|---|
| Validity of using serotonin transporter mRNA expression levels | Validity of using serotonin transporter mRNA expression levels in 5 HTTLPR:LL and rs 25531:AA genotype carriers, as a biomarker of alcohol consumption levels. | Within 24 hours of blood sample collection and in archived blood samples from the same participant stores at -80 degrees celsius for a duration of 6 months or more from the collection date |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Chamindi Seneviratne | csenevi@som.umaryland.edu | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinical Neurobehavioral Center | Columbia | Maryland | 21045 | United States |
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| ID | Term |
|---|---|
| D000437 | Alcoholism |
| ID | Term |
|---|---|
| D019973 | Alcohol-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D000431 | Ethanol |
| ID | Term |
|---|---|
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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