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| Name | Class |
|---|---|
| Universidade Federal do Rio Grande do Norte | OTHER |
Transcranial direct current stimulation has shown promising results in stroke patients. This study is a double blind, sham-controlled clinical trial aiming to compare the long-term effects of stimulation in two different cognitive regions after a stroke. Sixty patients who suffer from chronic strokes will be randomized into 1 of 3 groups: dorsolateral prefrontal cortex, cingulo-opercular network and motor primary cortex (control). Each group will receive transcranial direct current stimulation for 20 minutes for 10 consecutive working days (2 weeks). Patients will be assessed with a Dysexecutive Questionnaire, Semantic Fluency test, categorical verbal fluency and Go-no go tests, Wechsler Adult Intelligence Scale, Rey Auditory-Verbal Learning Test, Letter Comparison and Pattern Comparison Tasks at baseline, after their tenth stimulation session (week 2) and endpoint (week 4). Those who achieve clinical improvement with neurostimulation will be invited to receive treatment for 12 months as part of a follow-up study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| dlPFC | Experimental | Participants in the chronic post-stroke stage will receive active transcranial direct current stimulation in dorsolateral prefrontal cortex |
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| CON | Experimental | Participants in the chronic post-stroke stage will receive active transcranial direct current stimulation in cingulo-opercular network |
|
| M1 | Active Comparator | Participants in the chronic post-stroke stage will receive active transcranial direct current stimulation in motor primary cortex |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcranial direct current stimulation | Device |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Executive Function measured by Dysexecutive Questionnaire (DEX) | Change for executive functions at 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Verbal Fluency (Semantic Fluency Test) | [ Time Frame: Baseline, Week 2 and Week 4 ] | |
| Response inhibition (Go-no-go Test) | [ Time Frame: Baseline, Week 2 and Week 4 ] | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Suellen Andrade | Contact | suellenandrade@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Suellen Andrade, PhD | Federal University of ParaÃba | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Suellen Andrade | Recruiting | João Pessoa | ParaÃba | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26420269 | Derived | Andrade SM, Fernandez-Calvo B, Boggio PS, de Oliveira EA, Gomes LF, Pinheiro Junior JE, Rodrigues RM, de Almeida NL, Moreira GM, Alves NT. Neurostimulation for cognitive rehabilitation in stroke (NeuroCog): study protocol for a randomized controlled trial. Trials. 2015 Sep 29;16:435. doi: 10.1186/s13063-015-0945-1. |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| D060825 | Cognitive Dysfunction |
| D002544 | Cerebral Infarction |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| Executive function (Wechsler Intelligence Scale for Adults) |
| [ Time Frame: Baseline, Week 2 and Week 4 ] |
| Memory (Rey Auditory Verbal Learning) | [ Time Frame: Baseline, Week 2 and Week 4 ] |
| Processing Speed (Letter Comparison and Pattern Comparison Tasks) | [ Time Frame: Baseline, Week 2 and Week 4 ] |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D020520 | Brain Infarction |
| D002545 | Brain Ischemia |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |