Single center, open-label randomized-control trial Population: de novo 48 kidney transplant recipients (age 18-75 years) from ECD/AKI donors Compare: everolimus with low dose CNI and prednisolone versus standard immunosuppressive regimen Objective: To evaluate efficacy of everolimus with low dose CNI in de novo kidney transplant recipients of ECD/AKI donors Primary endpoint: Mean eGFR (CKD-EPI) at 12 months post-transplantation

Secondary Endpoints:

• To assess renal function by means of eGFR (Cockcrault and Gault formula), at -Month 6 and 12 post-transplantation
• To assess incidence of the individual composite endpoints including BPAR, graft loss and death at Month 6 and 12 post-transplantation
• To assess the incidence and duration of renal replacement therapy
• To assess the incidence of chronic allograft nephropathy (IF/TA) at Month 12
• To assess renal function by means of serum creatinine at Month 6 and 12 post-transplantation
• To compare the overall safety and tolerability (incidence of AEs and SAEs, infections, discontinuations due to AEs, lab abnormalities, wound and surgical complications) at Month 6 and 12 post-transplantation

Definition of ECD

• Brain-dead donor > 60 years old or
• Donor age > 50 years old with two of the following criteria;
• History of HT
• Terminal SCr. ≥ 1.5 mg/dL
• Death from cerebrovascular accident Definition of AKI donor
• Brain-dead donor with an increase of SCr. ≥ 0.3 mg/dL from baseline

Inclusion Criteria:

• Age 18-75 years
• Recipients of first DDKT from ECD or AKI donors
• Patient willing to participate in the study

Exclusion Criteria:

• Multi-organ recipients

  • Organ donation after Cardiac Death (DCD).
  • PRA > 20 % or with historical peak PRA > 50%
  • Patients who lost first graft due to immunological reason within the first year post-transplantation.
  • ABO incompatible transplants or positive cross-match
  • Patients with chronic inflammatory bowel disease.
  • Severe allergy requiring acute treatment, or any known hypersensitivity to everolimus, thymoglobulin
  • Thrombocytopenia (platelet < 75,000/mm3), ANC < 1,500 /mm3 or leucopenia (leucocytes < 2,500/mm3), or Hb < 6 g/dL
  • Chronic active HCV, HIV, or HBsAg positive
  • History of malignancy during the last five years, except squamous or basal cell carcinoma of the skin.
  • Ongoing infection requiring treatment with a systemic antibiotic.
  • Patient with severe hypercholesterolemia (> 300 mg/dL) or hypertriglyceridemia (> 600 mg/dL) that cannot be controlled
  • Evidence of severe liver disease.
  • Severe restrictive or obstructive pulmonary disorders.
  • Pregnant or nursing (lactating) women.
  • Patient who refuse to participate into the study or would like to withdraw from the study.