The number of fertilized oocytes (2-pronuclei) after standard in vitro fertilization or intra-cytoplasmic sperm injection divided by the total number of oocytes retrieved as a measure of oocyte competence.

The total number of oocytes recovered at the oocyte retrieval.

No outcome data for 1 participant that elected to convert to intrauterine insemination after trigger

The number of metaphase 2 oocytes (MII) recovered which can only be calculated in patients that underwent intracytoplasmic sperm injection.

This parameter can only be calculated in patients that underwent oocyte stripping to undergo intracytoplasmic sperm injection for fertilization method.

Oocyte maturity rate was determined by the number of meta phase 2 (MII) oocytes divided by the number of oocytes retrieved. This outcome was only assessed in patients undergoing intracytoplasmic sperm injection (ICSI).

This parameter can only be calculated in patients that underwent oocyte stripping to undergo intracytoplasmic sperm injection for fertilization method.

Mature oocyte recovery proportion is defined as the number of MIIs divided by the total number of follicles greater or equal to 13mm in size on trigger day.

This parameter can only be calculated in patients that underwent oocyte stripping to undergo intracytoplasmic sperm injection for fertilization method.

ICSI fertilization rate was determined by the number of 2 pro-nuclei (2PN) divided by the number of MII oocytes. This was only assessed in patients undergoing ICSI.

This parameter can only be calculated in patients that were undergoing intracytoplasmic sperm injection for fertilization method. One participant the low dose hCG plus FSH co-trigger arm was not included in the analysis as they underwent oocyte cryopreservation instead as the male partner was unable to produce fresh sperm sample to fertilize the oocytes.

Good quality embryo development was compared between trigger groups by calculating the ratio of good quality embryos to the total number of cleavage-stage embryos. A good quality cleavage-stage embryo was defined by having a cell number of 7 to 10 and <10% of cell fragmentation based on a modified Veeck's grading system.

No outcome data for 3 participants: 1) participant that elected to convert to intrauterine insemination after trigger; 2) participant that underwent oocyte cryopreservation due to male partner being unable to produce fresh sperm sample for fertilization; 3) cleavage-stage embryo quality was inadvertently not documented by the staff embryologist in one participant

A high quality blastocyst was defined as grade 3 or higher expansion plus inner cell mass and trophectoderm grading of A or B based on Gardner's criteria. The number describes the degree of embryo expansion on a scale from 1-6. As the embryo expands, the degree of expansion increases. The first letter indicates on a scale from A to C (A being the highest) the quality of the inner cell mass. The second letter is also on a scale from A to C (A being the highest) and indicates the quality of the trophectoderm.

Livebirth rate (LBR) was defined as a liveborn at the time of the analysis. Pregnancy outcomes were calculated for all fresh transfers.

Only patients that underwent a fresh embryo transfer can be included in this analysis. Not all participants underwent fresh embryo transfers.

Change in bloating scores from day of baseline ultrasound to post-trigger day 5.

The patient's clinical symptoms will be evaluated based on a bloating score reported by each patient on the day of ovulation trigger and then 5 days after the oocyte retrieval will be determined. The bloating score will range on a scale from 0-5. The number describes the degree of bloating and will increase as the degree of bloating increases. The bloating score will be determined as follows:

0 - No bloating

1. - Mild bloating. Able to continue daily activities without discomfort.
2. - Mild to moderate bloating. Able to continue daily activities but with mild discomfort.
3. - Moderate bloating. Able to continue daily activities but with moderate discomfort.
4. - Moderate to severe bloating. Difficulty performing daily activities.
5. - Severe bloating. Abdomen feels very tense and unable to perform daily activities.

Only patients that answered this question on the study questionnaire could be included in this analysis.

Change in abdominal circumference (in centimeters) from day of baseline ultrasound to post-trigger day 5.

Only patients that had their abdominal circumference measured on both day of baseline ultrasound and post-trigger day 5 could be included in this analysis.

Change in body weight from day of baseline ultrasound to post-trigger day 5.

Only patients that had their body weight measured on both day of baseline ultrasound and post-trigger day 5 could be included in this analysis.

Blood samples were collected about 12 hours after trigger (T+1) to assess the serum concentration of human chorionic gonadotropin (hCG).

Only comparisons to the standard 10,000 IU hCG trigger dose are presented using the per-protocol study population.

Blood samples were collected about 12 hours after trigger (T+1) to assess the serum concentration of follicle stimulating hormone (FSH).

Only comparisons to the standard 10,000 IU hCG trigger dose are presented using the per-protocol study population.

Blood samples were collected about 12 hours after trigger (T+1) to assess the serum concentration of Progesterone (P4).

Only comparisons to the standard 10,000 IU hCG trigger dose are presented using the per-protocol study population.

Blood samples were collected about 12 hours after trigger (T+1) to assess the serum concentration of estradiol (E2).

Only comparisons to the standard 10,000 IU hCG trigger dose are presented using the per-protocol study population.

Blood samples were collected about 12 hours after trigger (T+1) to assess the serum concentration of luteinizing hormone (LH).

Only comparisons to the standard 10,000 IU hCG trigger dose are presented using the per-protocol study population.

Blood samples were collected about 2 days after trigger (T+2) to assess the serum concentration of human chorionic gonadotropin (hCG).

Only comparisons to the standard 10,000 IU hCG trigger dose are presented using the per-protocol study population.

Blood samples were collected 2 days after trigger (T+2) to assess the serum concentration of follicle stimulating hormone (FSH).

Only comparisons to the standard 10,000 IU hCG trigger dose are presented using the per-protocol study population.

Blood samples were collected 2 days after trigger (T+2) to assess the serum concentration of progesterone (P4).

Only comparisons to the standard 10,000 IU hCG trigger dose are presented using the per-protocol study population.

Blood samples were collected 2 days after trigger (T+2) to assess the serum concentration of estradiol (E2).

Only comparisons to the standard 10,000 IU hCG trigger dose are presented using the per-protocol study population.

Blood samples were collected 5 days after trigger (T+5) to assess the serum concentration of human chorionic gonadotropin (hCG).

Only comparisons to the standard 10,000 IU hCG trigger dose are presented using the per-protocol study population.

Blood samples were collected 5 days after trigger (T+5) to assess the serum concentration of follicle stimulating hormone (FSH).

Only comparisons to the standard 10,000 IU hCG trigger dose are presented using the per-protocol study population.

Blood samples were collected about 5 days after trigger (T+5) to assess the serum concentration of luteinizing hormone (LH).

Only comparisons to the standard 10,000 IU hCG trigger dose are presented using the per-protocol study population.

Follicular fluid was individually aspirated at oocyte retrieval from the lead follicle in each ovary using a single lumen needle. The mean concentration between right and left follicles collected was compared to assess the follicular concentration of human chorionic gonadotropin (hCG).

Only comparisons to the standard 10,000 IU hCG trigger dose are presented using the per-protocol study population.

Follicular fluid was individually aspirated at oocyte retrieval from the lead follicle in each ovary using a single lumen needle. The mean concentration between right and left follicles collected was compared to assess the follicular concentration of follicle stimulating hormone (FSH).

Only comparisons to the standard 10,000 IU hCG trigger dose are presented using the per-protocol study population.

Follicular fluid was individually aspirated at oocyte retrieval from the lead follicle in each ovary using a single lumen needle. The mean concentration between right and left follicles collected was compared to assess the follicular concentration of progesterone (P4).

Follicular fluid was individually aspirated at oocyte retrieval from the lead follicle in each ovary using a single lumen needle. The mean concentration between right and left follicles collected was compared to assess the follicular concentration of estradiol (E2).

Only comparisons to the standard 10,000 IU hCG trigger dose are presented using the per-protocol study population.

Follicular fluid was individually aspirated at oocyte retrieval from the lead follicle in each ovary using a single lumen needle. The mean concentration between right and left follicles collected was compared to assess the follicular concentration of vascular endothelial growth factor (VEGF).

Only comparisons to the standard 10,000 IU hCG trigger dose are presented using the per-protocol study population.